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Titolo:
Allogeneic peripheral blood stem cell transplantation for the treatment ofchronic active Epstein-Barr virus infection
Autore:
Fujii, N; Takenaka, K; Hiraki, A; Maeda, Y; Ikeda, K; Shinagawa, K; Ashiba, A; Munemasa, M; Sunami, K; Hiramatsu, Y; Ishimaru, F; Niiya, K; Yoshino, T; Harada, M;
Indirizzi:
Okayama Univ, Sch Med, Dept Internal Med 2, Okayama 7008558, Japan OkayamaUniv Okayama Japan 7008558 nternal Med 2, Okayama 7008558, Japan Okayama Univ, Sch Med, Dept Pathol 2, Okayama 7008558, Japan Okayama UnivOkayama Japan 7008558 Dept Pathol 2, Okayama 7008558, Japan
Titolo Testata:
BONE MARROW TRANSPLANTATION
fascicolo: 7, volume: 26, anno: 2000,
pagine: 805 - 808
SICI:
0268-3369(200010)26:7<805:APBSCT>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MARROW TRANSPLANTATION; EBV INFECTION; MONONUCLEOSIS; LEUKEMIA; PATIENT;
Keywords:
chronic active Epstein-Barr virus infection; allogeneic peripheral blood stem cell transplantation; myeloablative conditioning regimen; EBV-specific CTL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Fujii, N Okayama Univ, Sch Med, Dept Internal Med 2, 2-5-1 Shikata Cho, Okayama 7008558, Japan Okayama Univ 2-5-1 Shikata Cho Okayama Japan 7008558 8558, Japan
Citazione:
N. Fujii et al., "Allogeneic peripheral blood stem cell transplantation for the treatment ofchronic active Epstein-Barr virus infection", BONE MAR TR, 26(7), 2000, pp. 805-808

Abstract

The prognosis of chronic active Epstein-Barr virus infection (CAEBV) is very poor. We describe a 24-year-old male with severe CAEBV who was treated with allogeneic peripheral blood stem cell transplantation (allo-PBSCT), On admission, EBER-1 in lymphocytes infiltrating the liver, EBV-DNA in peripheral blood mononuclear cells (PBMC) and monoclonal NK cell proliferation were confirmed. After unsuccessful chemotherapy, he received an allo-PBSCT from his HLA-identical sister. Although he died of pulmonary hemorrhage on day+19, EBV-DNA was undetectable by PCR in PBMC, and the post-mortem liver showed no EBER-1-positive lymphocytes. This experience suggests that EBV-positive lymphocytes in CAEBV may be eradicated by allo-PBSCT, thereby raising the possibility of a new treatment modality.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 14:28:50