Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
A physical, chemical, and mechanical study of lumbar vertebrae from normal, ovariectomized, and nandrolone decanoate-treated cynomolgus monkeys (Macaca fascicularis)
Autore:
Gadeleta, SJ; Boskey, AL; Paschalis, E; Carlson, C; Menschik, F; Baldini, T; Peterson, M; Rimnac, CM;
Indirizzi:
Hosp Special Surg, New York, NY 10021 USA Hosp Special Surg New York NY USA 10021 cial Surg, New York, NY 10021 USA Univ Minnesota, Minneapolis, MN USA Univ Minnesota Minneapolis MN USAUniv Minnesota, Minneapolis, MN USA Case Western Reserve Univ, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA
Titolo Testata:
BONE
fascicolo: 4, volume: 27, anno: 2000,
pagine: 541 - 550
SICI:
8756-3282(200010)27:4<541:APCAMS>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSFORM INFRARED-SPECTROSCOPY; FTIR MICROSPECTROSCOPIC ANALYSIS; ANABOLIC-STEROID TREATMENT; BONE-MINERAL CONTENT; TRABECULAR BONE; CANCELLOUS BONE; CALCIUM-PHOSPHATE; BEAGLE DOGS; OSTEOPOROSIS; MICE;
Keywords:
osteoporosis; animal model; monkey; Fourier transform infrared microspectroscopy (FTIRM); bone mineral crystallinity; nandrolone decanoate; compression testing;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Boskey, AL Hosp Special Surg, 535 E 70th St, New York, NY 10021 USA Hosp Special Surg 535 E 70th St New York NY USA 10021 10021 USA
Citazione:
S.J. Gadeleta et al., "A physical, chemical, and mechanical study of lumbar vertebrae from normal, ovariectomized, and nandrolone decanoate-treated cynomolgus monkeys (Macaca fascicularis)", BONE, 27(4), 2000, pp. 541-550

Abstract

Ovariectomized cynomolgus monkeys have previously been investigated as a nonhuman primate model of postmenopausal osteoporosis (Jerome et al., Bone Miner 9:527-540; 1994), In the present study, Fourier transform infrared microspectroscopy (FTIRM) was used to verify that differences ih bone mineral quality and quantity in the vertebrae of mature intact (INT) and ovariectomized (ovx) monkeys were analogous to those seen in osteoporotic and nondiseased human bones. FTIRM spectra were acquired from 15 trabeculae per vertebra from three ovx and three INT adult monkeys (mean age 8 years). These spectra were compared with those of both trabecular and previously reported osteonal bone obtained from 3 "normal" and 11 postmenopausal osteoporotic human subjects. While variations in the mineral:matrix ratio (mineral content), carbonate:phosphate ratio, and crystallinity are typical for trabecular bone from iliac crests of normal human subjects, the values of these parameters were relatively static for trabecular bone from postmenopausal osteoporotic human subjects. In general, trabecular bone from postmenopausal osteoporotic human subjects exhibited decreased mineral content (1.0 +/- 0.5 vs. 2.9 +/- 0.6), increased crystallinity, and increased carbonate: phosphate relative to controls. Similarly, trabecular bone from ovariectomized monkeysexhibited lower mineral content (5.8 +/- 0.2) compared with the INT group (6.2 +/- 0.2; p less than or equal to 0.05) and contained larger/more perfect apatite crystals (increased crystallinity) with increased carbonate:phosphate ratios. Variations in absolute values were attributable to site differences (ilium vs. vertebrae). To appreciate the importance of mineral properties on mechanical properties, compression testing was performed using cores of monkey L-3 and L-4 vertebral bodies from a separate group of monkeys. Treating monkeys with the anabolic steroid nandrolone decanoate (ND) immediately after ovariectomy and for the next 24 months (ND group), or beginning 12 months after ovariectomy (dND group), increased the ultimate stress compared with an ovx treatment group, despite large interanimal variations inbone architecture and mechanical properties, These data support the hypothesis that ovariectomized adult monkeys are an excellent model for postmenopausal osteoporosis, and can be used for the evaluation of therapeutic modalities. (Bone 27:541-650; 2000) (C) 2000 by Elsevier Science Inc. All rightsreserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/10/20 alle ore 22:56:54