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Titolo:
Ex vivo synthesis of articular cartilage
Autore:
LeBaron, RG; Athanasiou, KA;
Indirizzi:
Rice Univ, Dept Bioengn, Houston, TX 77251 USA Rice Univ Houston TX USA 77251 Univ, Dept Bioengn, Houston, TX 77251 USA Univ Texas, Lab Extracellular Matrix & Cell Adhes Res, Div Life Sci, San Antonio, TX 78249 USA Univ Texas San Antonio TX USA 78249 v Life Sci, San Antonio, TX 78249 USA
Titolo Testata:
BIOMATERIALS
fascicolo: 24, volume: 21, anno: 2000,
pagine: 2575 - 2587
SICI:
0142-9612(200012)21:24<2575:EVSOAC>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR-BETA; IN-VITRO; ALLOGRAFT CHONDROCYTES; BIOSYNTHETIC RESPONSE; MECHANICAL-PROPERTIES; BIOREACTOR SYSTEM; COMPRESSIVE FORCE; CELL ATTACHMENT; COLLAGEN GEL; HUMAN BONE;
Keywords:
articular cartilage repair; tissue engineering; biodegradable scaffolds; peptides; chondrocytes; bioreactors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
78
Recensione:
Indirizzi per estratti:
Indirizzo: Athanasiou, KA Rice Univ, Dept Bioengn, MS 142,POB 1892, Houston, TX 77251USA Rice Univ MS 142,POB 1892 Houston TX USA 77251 TX 77251 USA
Citazione:
R.G. LeBaron e K.A. Athanasiou, "Ex vivo synthesis of articular cartilage", BIOMATERIAL, 21(24), 2000, pp. 2575-2587

Abstract

This review discusses modern methods used for the synthesis of articular cartilage ex vivo. The value of culturing articular chondrocytes as a monolayer and in three-dimensional lattices is discussed. Of particular interest are techniques involving seeding of chondrocytes onto synthetic, biodegradable, polymeric scaffolds, and natural materials, such as collagen and agarose. Also discussed is the use of bioreactors to modulate the fluid-flow-induced shear environment of cell-seeded scaffolds. Biodegradable scaffolds are central to the efforts to tissue engineer articular cartilage ex vivo. A review of salient efforts to design and use such scaffolds is presented, along with our thoughts on potential future improvements. (C) 2000 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 06:39:37