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Titolo:
Evaluation of multiphase implants for repair of focal osteochondral defects in goats
Autore:
Niederauer, GG; Slivka, MA; Leatherbury, NC; Korvick, DL; Harroff, HH; Ehler, WC; Dunn, CJ; Kieswetter, K;
Indirizzi:
OsteoBiol Inc, San Antonio, TX 78249 USA OsteoBiol Inc San Antonio TX USA78249 iol Inc, San Antonio, TX 78249 USA Univ Texas, Hlth Sci Ctr, Dept Lab Anim Resources, San Antonio, TX 78284 USA Univ Texas San Antonio TX USA 78284 Resources, San Antonio, TX 78284 USA Wilford Hall USAF Med Ctr, Lab Anim Resources Div, Lackland AFB, TX 78236 USA Wilford Hall USAF Med Ctr Lackland AFB TX USA 78236 and AFB, TX 78236 USA CJD Pharmacol Consultants LC, Richland, MI 49083 USA CJD Pharmacol Consultants LC Richland MI USA 49083 Richland, MI 49083 USA
Titolo Testata:
BIOMATERIALS
fascicolo: 24, volume: 21, anno: 2000,
pagine: 2561 - 2574
SICI:
0142-9612(200012)21:24<2561:EOMIFR>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
BIODEGRADABLE POLYMER SCAFFOLDS; TISSUE-ENGINEERED CARTILAGE; ARTICULAR-CARTILAGE; MECHANICAL-PROPERTIES; FEMORAL CARTILAGE; PERFUSION CULTURE; FIBER STRUCTURES; WEIGHT-BEARING; LESIONS; CHONDROCYTES;
Keywords:
(4-6) cartilage repair; resorbable polymer; ceramic; osteochondral; tissue engineering; mechanics;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
68
Recensione:
Indirizzi per estratti:
Indirizzo: Niederauer, GG OsteoBiol Inc, 12500 Network,Suite 112, San Antonio, TX 78249 USA OsteoBiol Inc 12500 Network,Suite 112 San Antonio TX USA 78249
Citazione:
G.G. Niederauer et al., "Evaluation of multiphase implants for repair of focal osteochondral defects in goats", BIOMATERIAL, 21(24), 2000, pp. 2561-2574

Abstract

The use of biodegradable scaffolds for articular cartilage repair has beeninvestigated by numerous researchers. The objective of this screening study was to examine how the mechanical and physical properties of four multiphase implants can affect the cartilage healing response. Multiphase implant prototypes were prepared using poly(D,L)lactide-co-glycolide as the base material. PGA fibers (FR), 45S5 Bioglass(R) (BG) and medical grade calcium sulfate (MGCS) were used as additives to vary stiffness and chemical properties. Osteochondral defects (3 mm dia. and 4 mm in depth) were created bilaterally in the medial femoral condyle thigh-weight bearing) and the distal medial portion of the patellar groove (low-weight bearing) of 16 Spanish goats. Half of the implants were loaded with autologous costochondral chondrocytes. Defect sites (total n = 64, 4 sites/treatment) were randomly treated and allowed to heal for 16 weeks, fully weight bearing. At euthanasia, grossevaluations and biomechanical testing were conducted. Histological sections of the defect sites were stained with H and E, Safranin O/Fast Green or processed to analyze collagen architecture. Sections were semi-quantitatively scored for repair tissue structure. Qualitative evaluations showed that all groups had a high percentage of hyaline cartilage and good bony restoration, with new tissue integrating well with the native cartilage. Gross and histology scoring indicated a significantly higher score for defect healingin the condyle than in the patellar groove, but no difference in heating for implant types or addition/omission of cells was found. This investigation demonstrates that focal, osteochondral defects in caprine distal femurs treated with various implant constructs were repaired with hyaline-like cartilage and good underlying bone. The multiphase implants show potential for treatment of osteochondral defects and long-term studies need to be undertaken to confirm the longevity of the regenerated tissue. (C) 2000 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 14:55:50