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Titolo:
The brain link protein-1 (BRAL1): cDNA cloning, genomic structure, and characterization as a novel link protein expressed in adult brain
Autore:
Hirakawa, S; Oohashi, T; Su, WD; Yoshioka, H; Murakami, T; Arata, J; Ninomiya, Y;
Indirizzi:
Okayama Univ, Sch Med, Dept Biochem & Mol Biol, Okayama 7008558, Japan Okayama Univ Okayama Japan 7008558 em & Mol Biol, Okayama 7008558, Japan Okayama Univ, Sch Med, Dept Dermatol, Okayama 7008558, Japan Okayama UnivOkayama Japan 7008558 Dept Dermatol, Okayama 7008558, Japan Okayama Univ, Sch Med, Dept Anat, Okayama 7008558, Japan Okayama Univ Okayama Japan 7008558 ed, Dept Anat, Okayama 7008558, Japan Oita Med Univ, Dept Biochem, Oita 8795593, Japan Oita Med Univ Oita Japan 8795593 Univ, Dept Biochem, Oita 8795593, Japan
Titolo Testata:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
fascicolo: 3, volume: 276, anno: 2000,
pagine: 982 - 989
SICI:
0006-291X(20001005)276:3<982:TBLP(C>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHONDROITIN SULFATE PROTEOGLYCAN; EXTRACELLULAR ENVIRONMENT; CHROMOSOMAL LOCALIZATION; NEUROCAN GENE; HYALURONAN; SEQUENCE; CD44; AGGRECAN; VERSICAN; DOMAIN;
Keywords:
link protein; lectican proteoglycan; hyaluronan; brain;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Oohashi, T Okayama Univ, Sch Med, Dept Biochem & Mol Biol, 2-5-1 Shikata Cho, Okayama7008558, Japan Okayama Univ 2-5-1 Shikata Cho Okayama Japan 7008558 58, Japan
Citazione:
S. Hirakawa et al., "The brain link protein-1 (BRAL1): cDNA cloning, genomic structure, and characterization as a novel link protein expressed in adult brain", BIOC BIOP R, 276(3), 2000, pp. 982-989

Abstract

We report here molecular cloning and expression analysis of the gene for anovel human brain link protein-1 (BRAL1) which is predominantly expressed in brain. The predicted open reading frame of human brain link protein-1 encoded a polypeptide of 340 amino acids containing three protein modules, the immunoglobulin-like fold and proteoglycan tandem repeat 1 and 2 domains, with an estimated mass of 38 kDa. The brain link protein-1 mRNA was exclusively present in brain. When analyzed during mouse development, it was detected solely in the adult brain. Concomitant expression pattern of mRNAs for brain link protein-1 and various lectican proteoglycans in brain suggests apossibility that brain link protein-1 functions to stabilize the binding between hyaluronan and brevican, The human BRAL1 gene contained 7 exons and spanned similar to 6 kb. The entire immunoglobulin-like fold was encoded bya single exon and the proteoglycan tandem repeat I and 2 domains were encoded by a single and two exons, respectively. The deduced amino acid sequence of human brain link protein-1 exhibited 45% identity with human cartilagelink protein-1 (CRTL1), previously reported as link protein to stabilize aggregates of aggrecan and hyaluronan in cartilage. These results suggest that brain link protein-1 may have distinct function from cartilage link protein-1 and play specific roles, especially in the adult brain. (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 04:00:54