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Titolo:
Acute and chronic effects of alcohol on preattentive auditory processing as reflected by mismatch negativity
Autore:
Ahveninen, J; Escera, C; Polo, MD; Grau, C; Jaaskelainen, IP;
Indirizzi:
Univ Helsinki, Dept Psychol, Cognit Brain Res Unit, FIN-00014 Helsinki, Finland Univ Helsinki Helsinki Finland FIN-00014 it, FIN-00014 Helsinki, Finland Univ Helsinki, Cent Hosp, BioMag Lab, Helsinki, Finland Univ Helsinki Helsinki Finland Cent Hosp, BioMag Lab, Helsinki, Finland Univ Helsinki, Dept Neurol, Helsinki, Finland Univ Helsinki Helsinki Finland Helsinki, Dept Neurol, Helsinki, Finland Univ Barcelona, Dept Psychiat & Clin Psychobiol, Neurodynam Lab, E-08007 Barcelona, Spain Univ Barcelona Barcelona Spain E-08007 nam Lab, E-08007 Barcelona, Spain
Titolo Testata:
AUDIOLOGY AND NEURO-OTOLOGY
fascicolo: 6, volume: 5, anno: 2000,
pagine: 303 - 311
SICI:
1420-3030(200011/12)5:6<303:AACEOA>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
EVENT-RELATED POTENTIALS; POSITRON-EMISSION-TOMOGRAPHY; GABA-BENZODIAZEPINE RECEPTOR; ABSTINENT CHRONIC-ALCOHOLICS; CEREBRAL BLOOD-FLOW; SENSORY MEMORY; ETHANOL WITHDRAWAL; FRONTAL HYPOMETABOLISM; SELECTIVE-ATTENTION; EVOKED-POTENTIALS;
Keywords:
alcohol; alcoholism; attention; auditory sensory memory; brain; ethanol; event-related potentials; mismatch negativity (MMN); P3a;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
120
Recensione:
Indirizzi per estratti:
Indirizzo: Ahveninen, J Univ Helsinki, Dept Psychol, Cognit Brain Res Unit, POB 13, FIN-00014 Helsinki, Finland Univ Helsinki POB 13 Helsinki Finland FIN-00014nki, Finland
Citazione:
J. Ahveninen et al., "Acute and chronic effects of alcohol on preattentive auditory processing as reflected by mismatch negativity", AUDIOL NEUR, 5(6), 2000, pp. 303-311

Abstract

Chronic alcoholism, a major worldwide health problem, is associated with avariety of neurocognitive changes in the afflicted individuals. The precise neurophysiological basis of these changes is not yet understood. Mismatchnegativity (MMN) is a preattentive event-related potential component indexing cortical auditory memory traces and automatic change detection in the brain that can be used to study the neural basis of cognitive impairments invarious neurodegenerative diseases. MMN studies have revealed that even a low dose of acute alcohol significantly impairs automatic change detection and involuntary attention shifting. Recent MMN results on chronic alcoholism in turn suggest that auditory sensory traces decay slightly faster and are substantially more vulnerable to the distracting effect of backward masking in alcoholics than in healthy subjects. Furthermore, chronic alcohol abuse might accelerate the age-related impairment of automatic change detection. There is also evidence that the MMN changes might predict impaired performance in behavioral memory and attention tasks in alcoholics. In MMN studies of detoxified alcoholics, however, many confounding factors have to be taken into account. For instance, postwithdrawal brain hyper excitability might be associated with a slightly enhanced or accelerated MMN/MMNm (the magnetic equivalent of MMN). In sum, MMN and MMNm provide an objective noninvasive tool for exploring the neurophysiological functional deficits related to both acute alcohol intoxication and chronic alcoholism. Copyright (C) 2000 S.Karger AG. Basel.

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Documento generato il 03/04/20 alle ore 03:54:00