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Titolo:
Apoptosis signaling
Autore:
Strasser, A; OConnor, L; Dixit, VM;
Indirizzi:
Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3050, Australia Walter & Eliza Hall Inst Med Res Melbourne Vic Australia 3050 , Australia Genentech Inc, S San Francisco, CA 94080 USA Genentech Inc S San Francisco CA USA 94080 S San Francisco, CA 94080 USA
Titolo Testata:
ANNUAL REVIEW OF BIOCHEMISTRY
, volume: 69, anno: 2000,
pagine: 217 - 245
SICI:
0066-4154(2000)69:<217:AS>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRAMMED CELL-DEATH; TUMOR-NECROSIS-FACTOR; NF-KAPPA-B; DOMAIN-CONTAINING RECEPTOR; BCL-X-L; INTERLEUKIN-1-BETA CONVERTING-ENZYME; FACTOR RECEPTOR-1-INDUCED APOPTOSIS; SURVIVAL-PROMOTING PROTEINS; FADD-DEPENDENT APOPTOSIS; INHIBITS MULTIPLE FORMS;
Keywords:
cell death; bcl-2 protein family; tumor necrosis factor receptor family; cysteine proteases; development;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
289
Recensione:
Indirizzi per estratti:
Indirizzo: Strasser, A Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3050, Australia Walter & Eliza Hall Inst Med Res Melbourne Vic Australia 3050
Citazione:
A. Strasser et al., "Apoptosis signaling", ANN R BIOCH, 69, 2000, pp. 217-245

Abstract

Apoptosis, a physiological process for killing cells, is critical for the normal development and function of multicellular organisms. Abnormalities in cell death control can contribute to a variety of diseases, including cancer, autoimmunity, and degenerative disorders. Signaling for apoptosis occurs through multiple independent pathways that are initiated either from triggering events within the cell or from outside the cell, for instance, by ligation of death receptors. All apoptosis signaling pathways converge on a common machinery of cell destruction that is activated by a family of cysteine proteases (caspases) that cleave proteins at aspartate residues. Dismantling and removal of doomed cells is accomplished by proteolysis of vital cellular constituents, DNA degradation, and phagocytosis by neighboring cells. This article reviews current knowledge of apoptosis signaling, lists several pressing questions, and presents a novel model to explain the biochemical and functional interactions between components of the cell death regulatory machinery.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 10:57:56