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Titolo:
Effect of a 30-minute infusion of dobutamine hydrochloride on hind limb blood flow and hemodynamics in halothane-anesthetized horses
Autore:
Raisis, AL; Young, LE; Blissitt, KJ; Walsh, K; Meire, HB; Taylor, PM; Lekeux, P;
Indirizzi:
Anim Hlth Trust, Ctr Equine Studies, Newmarket CB8 8JH, Suffolk, England Anim Hlth Trust Newmarket Suffolk England CB8 8JH 8 8JH, Suffolk, England
Titolo Testata:
AMERICAN JOURNAL OF VETERINARY RESEARCH
fascicolo: 10, volume: 61, anno: 2000,
pagine: 1282 - 1288
SICI:
0002-9645(200010)61:10<1282:EOA3IO>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
MUSCLE PERFUSION; DOPAMINE; ECHOCARDIOGRAPHY; ANESTHESIA; THERAPY; PONIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Raisis, AL Anim Hlth Trust, Ctr Equine Studies, POB 5, Newmarket CB8 8JH, Suffolk, England Anim Hlth Trust POB 5 Newmarket Suffolk England CB8 8JH England
Citazione:
A.L. Raisis et al., "Effect of a 30-minute infusion of dobutamine hydrochloride on hind limb blood flow and hemodynamics in halothane-anesthetized horses", AM J VET RE, 61(10), 2000, pp. 1282-1288

Abstract

Objective-To evaluate the hemodynamic effects of dobutamine hydrochloride (0.5 mu g/kg of body weight/min) in halothane-anesthetized horses. Animals-6 adult Thoroughbred horses. Procedure-Anesthesia was induced by use of romifidine (200 mu g/kg) and ketamine (2.2 mg/kg), IV. Anesthesia was maintained by halothane (end-tidal concentration 0.9 to 1.0%). Aortic, left ventricular, and right atrial pressures were measured, using catheter-mounted strain gauge transducers. Cardiac output (CO) velocity time integral, maxima[ aortic blood flow velocity and acceleration, and left ventricular preejection period and ejection time were measured from aortic velocity waveforms obtained by transesophageal Doppler echocardiography. Velocity waveforms were recorded from the femoral vessels, using Doppler ultrasonography. The time-averaged mean velocity and early diastolic deceleration slope (EDDS) were measured. Pulsatility index (PI) and volumetric flow were calculated. Microvascular perfusion was measured in the semimembranosus muscles by laser Doppler flowmetry. Data were recorded 60 minutes after induction of anesthesia (control) and at 15 and 30 minutes after start of an infusion of dobutamine (0.5 mu g/kg/min). Results-Aortic pressures were significantly increased during the infusion of dobutamine. No change was observed in the indices of left ventricular systolic function including CO. Femoral arteria[ flow significantly increased, and the PI and EDDS decreased. No change was observed in the femoral venous flow or in microvascular perfusion. Conclusions and Clinical Relevance-At this dosage, dobutamine did not alter left ventricular systolic function. Femoral blood flow was preferentiallyincreased as the result of local vasodilatation. The lack of effect of dobutamine on microvascular perfusion suggests that increased femoral flow is not necessarily associated with improved perfusion of skeletal muscles.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 16:44:19