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Titolo:
Stem cell factor (SCF) concentrations in peritoneal fluid of women with orwithout endometriosis
Autore:
Osuga, Y; Koga, K; Tsutsumi, O; Igarashi, T; Okagaki, R; Takai, Y; Matsumi, H; Hiroi, H; Fujiwara, T; Momoeda, M; Yano, T; Taketani, Y;
Indirizzi:
Univ Tokyo, Dept Obstet & Gynecol, Tokyo 1138655, Japan Univ Tokyo TokyoJapan 1138655 pt Obstet & Gynecol, Tokyo 1138655, Japan Japan Sci & Technol, CREST, Kawaguchi 3320012, Japan Japan Sci & Technol Kawaguchi Japan 3320012 ST, Kawaguchi 3320012, Japan
Titolo Testata:
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
fascicolo: 4, volume: 44, anno: 2000,
pagine: 231 - 235
SICI:
1046-7408(200010)44:4<231:SCF
Fonte:
ISI
Lingua:
ENG
Soggetto:
C-KIT LIGAND; MAST-CELLS; GROWTH-FACTOR; TNF-ALPHA; INTERLEUKIN-6; EXPRESSION; CYTOKINE; DISEASE; INFLAMMATION; COLLAGEN;
Keywords:
C-kit; endometriosis; peritoneal fluid; stem cell factor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Taketani, Y Univ Tokyo, Dept Obstet & Gynecol, Tokyo 1138655, Japan Univ Tokyo Tokyo Japan 1138655 Gynecol, Tokyo 1138655, Japan
Citazione:
Y. Osuga et al., "Stem cell factor (SCF) concentrations in peritoneal fluid of women with orwithout endometriosis", AM J REPROD, 44(4), 2000, pp. 231-235

Abstract

PROBLEM: In the quest for possible involvement of stem cell factor (SCF), a cytokine known to have multiple effects, in the pathogenesis of endometriosis, we evaluated concentrations of SCF in peritoneal fluid (PF) of women with or without endometriosis. METHOD OF STUDY: SCF concentrations in PF collected from women undergoing laparoscopy were measured, using a specific enzyme-linked immunosorbent assay (ELISA). Reverse transcription-polymerase chain reaction (RT-PCR) analysis to detect gene expression of c-kit, the receptor for SCF, was performed using the endometriotic tissue and the eutopic endometrium collected duringthe operation. RESULTS: SCF concentrations in PF of women with endometriosis were significantly higher compared to women without endometriosis. Looking at SCF concentrations in PF of women with endometriosis stratified by disease stage, women with stage I and II exhibited relatively higher SCF levels in PF, whereas SCF levels in PF with stage III and IV were comparable with those without endometriosis. The expression of mRNA for c-kit was detected in both the endometriotic tissue and the eutopic endometrium. CONCLUSION: We demonstrated an elevation in SCF levels in PF associated with endometriosis and the presence of its receptor in endometriotic tissues. Given the known pleiotropic properties of SCF, the present results suggestthat SCF might play a role in the pathogenesis of endometriosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 02:45:03