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Titolo:
Results of breast-conserving therapy for early stage breast cancer - KyotoUniversity experiences
Autore:
Kokubo, M; Mitsumori, M; Ishikura, S; Nagata, Y; Fujishiro, S; Inamoto, T; Mise, K; Kodama, H; Sasai, K; Hiraoka, M;
Indirizzi:
Kyoto Univ, Grad Sch Med, Dept Therapeut Radiol & Oncol, Sakyo Ku, Kyoto 6068507, Japan Kyoto Univ Kyoto Japan 6068507 l & Oncol, Sakyo Ku, Kyoto 6068507, Japan Kyoto Univ, Grad Sch Med, Dept Surg Gastroenterol, Kyoto 6068507, Japan Kyoto Univ Kyoto Japan 6068507 Surg Gastroenterol, Kyoto 6068507, Japan Kodama Breast Clin, Kyoto, Japan Kodama Breast Clin Kyoto JapanKodama Breast Clin, Kyoto, Japan Natl Canc Ctr Hosp E, Div Radiat Oncol, Chiba, Japan Natl Canc Ctr Hosp EChiba Japan Hosp E, Div Radiat Oncol, Chiba, Japan
Titolo Testata:
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
fascicolo: 5, volume: 23, anno: 2000,
pagine: 499 - 505
SICI:
0277-3732(200010)23:5<499:ROBTFE>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONSERVATIVE SURGERY; RADIATION-THERAPY; LOCAL RECURRENCE; LYMPH-NODES; FOLLOW-UP; MASTECTOMY; RADIOTHERAPY; RISK; IRRADIATION; CARCINOMAS;
Keywords:
breast cancer; breast-conserving therapy; BCT; breast-conserving surgery; radiation therapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Kokubo, M Kyoto Univ, Grad Sch Med, Dept Therapeut Radiol & Oncol, Sakyo Ku, 54 Kawahara Cho, Kyoto 6068507, Japan Kyoto Univ 54 Kawahara Cho Kyoto Japan 6068507 o 6068507, Japan
Citazione:
M. Kokubo et al., "Results of breast-conserving therapy for early stage breast cancer - KyotoUniversity experiences", AM J CL ONC, 23(5), 2000, pp. 499-505

Abstract

This study evaluated the results of breast-conserving therapy (BCT). Nine hundred six patients who underwent BCT at our hospital between November 1987 and February 1998 were analyzed. The mean age was 48 years. According to the Union Internationale Contre le Cancer 1997 classification system, stages 0, I, IIA, IIB, IIIA, and IIIB were 37, 400, 344, 117, 7, and 1, respectively. Radiation therapy consisted of 50 Gy to the ipsilateral whole breast. Boost irradiation of 10 Gy was administered to 186 of 231 patients with close or positive margins. Nearly all patients received adjuvant chemohormonal therapy with tamoxifen and 5-fluorouracil or its derivatives for 2 years. The minimum and median follow-up periods were 18 and 52 months, respectively. The 5-year overall survival, cause-specific survival, local recurrence-free survival, and disease-free survival rates were 97.3%, 98.4%, 98.1%, and 91.5%, respectively. Local recurrence in preserved breast occurred in 20 patients 7 to 86 months after surgery. Multivariate analysis revealed that the most predictive factor for disease-free survival rates and distant failures was the number of pathologically positive lymph nodes (p < 0.0001), and that the factor for local failure was marginal status (p = 0.005). This study demonstrated that BCT was suitable for the treatment of early-stage breast cancer with its reasonable survival rates and acceptable toxicity.

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Documento generato il 04/04/20 alle ore 21:42:43