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Titolo:
Myxoma virus expresses a TNF receptor homolog with two distinct functions
Autore:
Xu, XM; Nash, P; McFadden, G;
Indirizzi:
Univ Western Ontario, Dept Microbiol & Immunol, London, ON N6G 2V4, CanadaUniv Western Ontario London ON Canada N6G 2V4 London, ON N6G 2V4, Canada John P Robarts Res Inst, London, ON N6G 2V4, Canada John P Robarts Res Inst London ON Canada N6G 2V4 ndon, ON N6G 2V4, Canada Univ Alberta, Dept Biochem, Edmonton, AB T6G 2H7, Canada Univ Alberta Edmonton AB Canada T6G 2H7 hem, Edmonton, AB T6G 2H7, Canada
Titolo Testata:
VIRUS GENES
fascicolo: 1-2, volume: 21, anno: 2000,
pagine: 97 - 109
SICI:
0920-8569(200008)21:1-2<97:MVEATR>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; SHOPE FIBROMA VIRUS; SERINE PROTEINASE-INHIBITOR; CYTOTOXIC LIGAND TRAIL; MOLECULAR-CLONING; FACTOR-ALPHA; TUMORIGENIC POXVIRUSES; CYTOKINE NETWORKS; INDUCED APOPTOSIS; VACCINIA VIRUS;
Keywords:
myxoma virus; immune-modulator; viroceptor; TNF receptor; apoptosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
74
Recensione:
Indirizzi per estratti:
Indirizzo: Xu, XM Univ Western Ontario, Dept Microbiol & Immunol, London, ON N6G 2V4,Canada Univ Western Ontario London ON Canada N6G 2V4 , ON N6G 2V4, Canada
Citazione:
X.M. Xu et al., "Myxoma virus expresses a TNF receptor homolog with two distinct functions", VIRUS GENES, 21(1-2), 2000, pp. 97-109

Abstract

Myxoma virus, a member of the poxvirus family of DNA viruses, encodes manyvirulence factors to combat and evade the host immune responses. Among thevirus-encoded immune-modulators is M-T2, a tumor necrosis factor receptor (TNF-R) homologue. M-T2 is secreted as monomeric and dimeric species that bind and inhibit rabbit TNF in a species-specific manner. Deletion analysis indicates that the anti-TNF function is mediated by the first three of fourcysteine rich domains (CRDs) of M-T2. In addition, the intracellular form of M-T2 has the ability to block virus-induced apoptosis in lymphocytes, and the first two CRDs appear to be sufficient for this function. Although the mechanisms for the anti-TNF and anti-apoptotic functions of M-T2 are not yet fully defined, we postulate that these dual activities of M-T2 are mediated through different functional motifs and abrogate distinct cellular responses to virus infection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 10:12:42