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Titolo:
Immunomodulatory functions encoded by the E3 transcription unit of adenoviruses
Autore:
Burgert, HG; Blusch, JH;
Indirizzi:
Univ Munich, Genzentrum, Lehrstuhl Virol, Max von Pettenkofer Inst, D-81377 Munich, Germany Univ Munich Munich Germany D-81377 enkofer Inst, D-81377 Munich, Germany
Titolo Testata:
VIRUS GENES
fascicolo: 1-2, volume: 21, anno: 2000,
pagine: 13 - 25
SICI:
0920-8569(200008)21:1-2<13:IFEBTE>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; CELL-SURFACE EXPRESSION; GROWTH-FACTOR RECEPTOR; CLASS-I ANTIGENS; NF-KAPPA-B; HIGHLY ONCOGENIC ADENOVIRUS-12; CYTOTOXIC T-LYMPHOCYTES; TRANSFORMED RAT-CELLS; ENDOPLASMIC-RETICULUM; E3/19K PROTEIN;
Keywords:
adenovirus E3 proteins; E3 protein sequence comparison; immune evasion; interference with antigen presentation; CD95 (Fas/APO-1); apoptosis; receptor down-regulation; TNF mediated lysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
96
Recensione:
Indirizzi per estratti:
Indirizzo: Burgert, HG Univ Munich, Genzentrum, Lehrstuhl Virol, Max von Pettenkofer Inst, FeodorLynen Str 25, D-81377 Munich, Germany Univ Munich Feodor Lynen Str 25 Munich Germany D-81377 ermany
Citazione:
H.G. Burgert e J.H. Blusch, "Immunomodulatory functions encoded by the E3 transcription unit of adenoviruses", VIRUS GENES, 21(1-2), 2000, pp. 13-25

Abstract

Persistent viruses have evolved multiple strategies to escape the host immune system. One important prerequisite for efficient viral reproduction in the face of an ongoing immune response is prevention of premature lysis of infected cells. A number of viruses achieve this goal by interfering with antigen presentation and recognition of infected cells by cytotoxic T cells (CTL). Another viral strategy aims to block apoptosis triggered by host defense mechanisms. Both types of strategies seem to be realized by human adenoviruses (Ads). The early transcription unit E3 of Ads encodes proteins that inhibit antigen presentation by MHC class I molecules as well as apoptosis induced by tumor necrosis factor alpha (TNF-alpha) and Fas ligand (FasL). Here, we will describe the organization of the E3 regions of different Ad subgroups and compare the structure and functions of the known immunomodulatory E3 proteins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 20:36:34