Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Accuracy of cyclosporin measurements made in capillary blood samples obtained by skin puncture
Autore:
Merton, G; Jones, K; Lee, M; Johnston, A; Holt, DW;
Indirizzi:
St George Hosp, Sch Med, Analyt Unit, London, England St George Hosp London England sp, Sch Med, Analyt Unit, London, England St Bartholomews & Royal London Sch Med & Dent, London, England St Bartholomews & Royal London Sch Med & Dent London England n, England
Titolo Testata:
THERAPEUTIC DRUG MONITORING
fascicolo: 5, volume: 22, anno: 2000,
pagine: 594 - 598
SICI:
0163-4356(200010)22:5<594:AOCMMI>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSPLANTATION; DRUGS; THEOPHYLLINE; REJECTION; STRATEGY; DEVICE; CURVE;
Keywords:
cyclosporin; capillary blood; therapeutic drug monitoring; finger prick; radioimmunoassay;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Holt, DW St George Hosp, Sch Med, Analyt Unit, Cranmer Terrace, London, England St George Hosp Cranmer Terrace London England , London, England
Citazione:
G. Merton et al., "Accuracy of cyclosporin measurements made in capillary blood samples obtained by skin puncture", THER DRUG M, 22(5), 2000, pp. 594-598

Abstract

international consensus guidelines suggest that cyclosporin should be measured in whole blood. In some instances it may be advantageous to collect capillary blood, by a finger or ear prick method. However, drug concentrations in skin-puncture blood mat. not necessarily correlate with those measuredin venous blood. This study compared cyclosporin concentrations in blood collected from the fingertip or earlobe with blood collected by standard venipuncture. Patient preference for each of the blood collection methods was also assessed. Specimens were obtained from organ transplant patients receiving cyclosporin, using each of the three methods: venipuncture, finger prick. and earlobe prick. The samples were assayed using a specific radioimmunoassay and the results were compared. In the 102 sets of samples collected,the mean difference (+/-standard deviation) in cyclosporin concentration between finger prick and venipuncture and ear prick and venipuncture was 2.6% (+/-9.5%) and 2.7% (+/-12.1%), respectively, while the comparable median (IQR) differences were 1.9% (-3.4% to +6.6%) and -1.1% (-2.8% to +7.2%), respectively. A high degree of correlation was observed between finger prick and venipuncture or ear prick and venipuncture or ear prick and finger prick (r(2) > 0.86). Of the three methods of blood collection, finger prick wasthe patients' preferred method (P < 0.01). These data suggest that capillary blood collected by skin puncture is suitable for use in cyclosporin blood monitoring and acceptable to patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 00:08:44