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Titolo:
Evaluation of limited sampling strategies for estimation of 12-hour mycophenolic acid area under the plasma concentration-time curve in adult renal transplant patients
Autore:
Willis, C; Taylor, PJ; Salm, P; Tett, SE; Pillans, PI;
Indirizzi:
Univ Queensland, Princess Alexandra Hosp, Dept Med, Brisbane, Qld 4102, Australia Univ Queensland Brisbane Qld Australia 4102 Brisbane, Qld 4102, Australia Univ Queensland, Sch Pharm, Brisbane, Qld, Australia Univ Queensland Brisbane Qld Australia h Pharm, Brisbane, Qld, Australia Princess Alexandra Hosp, Dept Clin Pharmacol, Brisbane, Qld 4102, Australia Princess Alexandra Hosp Brisbane Qld Australia 4102 , Qld 4102, Australia
Titolo Testata:
THERAPEUTIC DRUG MONITORING
fascicolo: 5, volume: 22, anno: 2000,
pagine: 549 - 554
SICI:
0163-4356(200010)22:5<549:EOLSSF>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
UNDER-THE-CURVE; ABBREVIATED KINETIC PROFILES; GLUCURONIDE METABOLITE; CYCLOSPORINE THERAPY; MOFETIL; PHARMACOKINETICS; RECIPIENTS; PERFORMANCE; REJECTION;
Keywords:
mycophenolic acid; limited sampling strategies; therapeutic drug monitoring;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Taylor, PJ Univ Queensland, Princess Alexandra Hosp, Dept Med, 1st Floor Lions Bldg,Ipswich Rd, Brisbane, Qld 4102, Australia Univ Queensland 1st Floor Lions Bldg,Ipswich Rd Brisbane Qld Australia 4102
Citazione:
C. Willis et al., "Evaluation of limited sampling strategies for estimation of 12-hour mycophenolic acid area under the plasma concentration-time curve in adult renal transplant patients", THER DRUG M, 22(5), 2000, pp. 549-554

Abstract

Mycophenolate mofetil, the oral prodrug of mycophenolic acid, is indicatedas immunosuppressive therapy after renal transplantation. To aid in the investigation of pharmacokinetic-pharmacodynamic relationships of mycophenolic acid in the clinical setting, limited blood sampling strategies have beenproposed, and models from these developed, for the estimation of mycophenolic acid area under the concentration-time curve (AUC). In the current study, the authors investigated the predictive performance of six published models to estimate AUG. A total of 49 profiles from 25 renal transplant patients were used to test each model's performance against a full 14 time-paint AUG. A wide range of agreement was found when predicted AUCs were compared with full AUCs using linear regression analysis (range: r(2) = 0.499 to 0.836). Model 1, which uses 4 time-points over 6 hours, was found to be superior to all Ether models. The range of time-points used in this model takes into account patients with variable absorption. This model should be furthertested on data sets from other centers. The relatively poor performance ofthe other models may be caused by their inability to describe the peak concentration in these patients. Caution is warranted when using limited sampling strategies on patients whose absorption of mycophenolic acid is altered, compared with those of the pharmacokinetic profiles from which the model was developed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 10:55:44