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Titolo:
Undifferentiated spindle-cell sarcoma of the chest wall with vascular endothelial growth factor expression: Report of a case
Autore:
Iyoda, A; Hiroshima, K; Yusa, T; Tsukamoto, Y; Toyozaki, T; Fujisawa, T; Ohwada, H;
Indirizzi:
Chiba Univ, Sch Med, Inst Pulm Canc Res, Div Pathol,Chuo Ku, Chiba 2608670, Japan Chiba Univ Chiba Japan 2608670 Div Pathol,Chuo Ku, Chiba 2608670, Japan
Titolo Testata:
SURGERY TODAY-THE JAPANESE JOURNAL OF SURGERY
fascicolo: 9, volume: 30, anno: 2000,
pagine: 831 - 834
SICI:
0941-1291(2000)30:9<831:USSOTC>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPIDERMOID LUNG-CARCINOMA; SOFT-TISSUE SARCOMAS; FACTOR VEGF; ANGIOGENESIS; CANCER; DENSITY; BFGF;
Keywords:
spindle cell sarcoma; chest wall; vascular endothelial growth factor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Iyoda, A Chiba Univ, Sch Med, Inst Pulm Canc Res, Div Pathol,Chuo Ku, 1-8-1 Inohana, Chiba 2608670, Japan Chiba Univ 1-8-1 Inohana Chiba Japan 2608670 hiba 2608670, Japan
Citazione:
A. Iyoda et al., "Undifferentiated spindle-cell sarcoma of the chest wall with vascular endothelial growth factor expression: Report of a case", SURG TODAY, 30(9), 2000, pp. 831-834

Abstract

The expressions of some growth factors have been immunohistochemically confirmed in several kinds of tumors, and in particular the expression of vascular endothelial growth factor (VEGF) has been reported to be closely related to tumor cell proliferation, We report herein a case of undifferentiatedspindle-cell sarcoma arising in the chest wall with VEGF expression. A 67-year-old man, who presented with coughing, was found to have an abnormal shadow on his right chest wall. He was admitted to Chiba Rosai Hospital and preoperative diagnosis of the tumor was sarcoma. The tumor was thus resectedalong with the right chest wall and right lower lobe of the lung. Histo pathologically, the tumor cells were spindle-shaped and showed severe atypism. The tumor cells were positive for vimentin and VEGF antibody with immunohistochemical staining, but they did not show differentiation to any specialtype of sarcoma. The tumor was diagnosed to be undifferentiated spindle-cell sarcoma. The microvessel density of the tumor was measured using CD34 and it was found to be higher than the average density of usual sarcomas. Theprognosis of this case was poor. The patient died of tumor metastasis to the lung and bone 1 year later in spite of the fact that the tumor was resected.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 01:10:15