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Titolo:
Lipid phosphatases in the immune system
Autore:
Krystal, G;
Indirizzi:
British Columbia Canc Agcy, Terry Fox Lab, Vancouver, BC V5Z 1L3, Canada British Columbia Canc Agcy Vancouver BC Canada V5Z 1L3 BC V5Z 1L3, Canada
Titolo Testata:
SEMINARS IN IMMUNOLOGY
fascicolo: 4, volume: 12, anno: 2000,
pagine: 397 - 403
SICI:
1044-5323(200008)12:4<397:LPITIS>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYPHOSPHATE 5-PHOSPHATASE SHIP; SH2-CONTAINING INOSITOL PHOSPHATASE; FC-GAMMA-RIIB; PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE; COLONY-STIMULATING FACTOR; AFFINITY IGE RECEPTOR; TUMOR-SUPPRESSOR PTEN; HEMATOPOIETIC-CELLS; SH2 DOMAIN; B-CELLS;
Keywords:
SHIP; SHIP2; PTEN; proliferation; apoptosis;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Krystal, G British Columbia Canc Agcy, Terry Fox Lab, 601 W 10th Ave, Vancouver, BC V5Z 1L3, Canada British Columbia Canc Agcy 601 W 10th Ave Vancouver BC Canada V5Z 1L3
Citazione:
G. Krystal, "Lipid phosphatases in the immune system", SEMIN IMMUN, 12(4), 2000, pp. 397-403

Abstract

In the last 10 years we have come to appreciate the central role that phosphatidylinositol (PI)-4,5-P-3 plays in regulating a vast array of biological responses to extracellular signals. The level of this phospholipid is lowin resting cells but increases rapidly in response to growth factor/cytokine-stimulated plasma membrane recruitment and activation of PI-3-kinase. Within the last 3 years three enzymes, SHIP: SHIP2 and PTEN, that play hey roles in regulating the level of PI-3,4,5-P3 have been cloned. In this reviewI have attempted to summarize our current knowledge regarding these three intriguing phosphatases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 09:47:34