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Titolo:
Intolerance to cereals is not specific for coeliac disease
Autore:
Kaukinen, K; Turjanmaa, K; Maki, M; Partanen, J; Venalainen, R; Reunala, T; Collin, P;
Indirizzi:
Univ Tampere, Sch Med, FIN-33014 Tampere, Finland Univ Tampere Tampere Finland FIN-33014 h Med, FIN-33014 Tampere, Finland Tampere Univ Hosp, Dept Internal Med, Tampere, Finland Tampere Univ Hosp Tampere Finland , Dept Internal Med, Tampere, Finland Tampere Univ Hosp, Dept Dermatol, Tampere, Finland Tampere Univ Hosp Tampere Finland Hosp, Dept Dermatol, Tampere, Finland Tampere Univ Hosp, Dept Paediat, Tampere, Finland Tampere Univ Hosp Tampere Finland Hosp, Dept Paediat, Tampere, Finland Univ Tampere, Inst Med Technol, FIN-33014 Tampere, Finland Univ Tampere Tampere Finland FIN-33014 chnol, FIN-33014 Tampere, Finland Finnish Red Cross, Blood Transfus Serv, Dept Tissue Typing Lab, Helsinki, Finland Finnish Red Cross Helsinki Finland Tissue Typing Lab, Helsinki, Finland
Titolo Testata:
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
fascicolo: 9, volume: 35, anno: 2000,
pagine: 942 - 946
SICI:
0036-5521(200009)35:9<942:ITCINS>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
LATENT CELIAC-DISEASE; INTESTINAL ANTIBODY PATTERN; LINKED-IMMUNOSORBENT-ASSAY; IRRITABLE-BOWEL-SYNDROME; DERMATITIS-HERPETIFORMIS; FOOD REACTIONS; ALLERGY; IGE; LYMPHOCYTES; EXPRESSION;
Keywords:
cereal allergy; coeliac disease; intraepithelial lymphocytes; latency;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Collin, P Univ Tampere, Sch Med, FIN-33014 Tampere, Finland Univ Tampere Tampere Finland FIN-33014 -33014 Tampere, Finland
Citazione:
K. Kaukinen et al., "Intolerance to cereals is not specific for coeliac disease", SC J GASTR, 35(9), 2000, pp. 942-946

Abstract

Background: Abdominal complaints after ingestion of cereals are not uncommon. We assessed how reliable such a history is as a marker for the presenceof overt coeliac disease, and whether we should also take into account latent coeliac disease and cereal allergy. Methods: The study group comprised 93 consecutive adults from health centres spontaneously reporting abdominalsymptoms after consumption of cereals. Small bowel mucosal morphology, CD3(+), alpha beta(+) and gamma delta(+) intraepithelial lymphocytes (IELs), HLA DQ alleles and serum IgA-class endomysial (EmA), tissue transglutaminase(tTg) and gliadin (AGA) antibodies were determined. Skin prick and patch tests and serum radioallergosorbent tests for cereals were carried out. Thirty non-coeliac adults served as biopsy controls. Results: Eight (9%) patients had coeliac disease and one mild partial villous atrophy. Altogether 17 had an increased density of gamma delta(+) IELs without atrophy. However, only seven (8%) showed evidence of latent coeliac disease, i.e. both an increase in gamma delta(+) IELs and the presence of coeliac disease-type HLA. One or more of the allergy tests for cereals was positive in 19; 9 adopted agluten-free diet and abdominal symptoms were alleviated in all. In non-coeliac patients, serum EmA and tTg tests were negative in all, whereas AGA was seen in 40%. Conclusions: Intolerance to cereals is not a specific sign of overt or latent coeliac disease. All experimental dietary interventions before proper diagnosis of coeliac disease are therefore to be discouraged. Allergy to cereals, on the other hand, should be considered even in adults.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 22:46:33