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Titolo:
Ketoconazole for the treatment of refractory hypercalcemic sarcoidosis
Autore:
Conron, M; Beynon, HLC;
Indirizzi:
Royal Free Hosp, Dept Med, London NW3 2QG, England Royal Free Hosp London England NW3 2QG Dept Med, London NW3 2QG, England
Titolo Testata:
SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES
fascicolo: 3, volume: 17, anno: 2000,
pagine: 277 - 280
SICI:
1124-0490(200010)17:3<277:KFTTOR>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
CULTURED ALVEOLAR MACROPHAGES; SERUM 1,25-DIHYDROXYVITAMIN-D; INDUCED REDUCTION; VITAMIN-D; CALCIUM; METABOLISM;
Keywords:
sarcoidosis; hypercalcemia; ketoconazole;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Beynon, HLC Royal Free Hosp, Dept Med, Pond St,Belsize Pk, London NW3 2QG,England Royal Free Hosp Pond St,Belsize Pk London England NW3 2QG and
Citazione:
M. Conron e H.L.C. Beynon, "Ketoconazole for the treatment of refractory hypercalcemic sarcoidosis", SARCO VASC, 17(3), 2000, pp. 277-280

Abstract

Hypercalcemia is a recognised complication of sarcoidosis due to excess 1,25-hydroxyvitamin D-3 production by macrophages. Systemic corticosteroids inhibit 1,25-hydroxyvitamin D-3 production, but long term therapy is often required to maintain normocalcemia. Ketoconazole is an imidazole antifungal that inhibits macrophage 1 alpha-hydroxylation of 25-hydroxyvitamin D-3 andhas been used in paraneoplastic hypercalcemia. We report a case series of four patients with relative contraindications to corticosteroids in whom treatment with ketoconazole allowed cessation or reduction in the maintenancedose of corticosteroids. We conclude that ketoconazole should be considered as an alternative therapy for hypercalcemic sarcoidosis when corticosteroids are relatively contraindicated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 11:05:30