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Titolo:
Effects of low-dose neutrons applied at reduced dose rate on human melanoma cells
Autore:
Dionet, C; Tchirkov, A; Alard, JP; Arnold, J; Dhermain, J; Rapp, M; Bodez, V; Tamain, JC; Monbel, I; Malet, P; Kwiatkowski, F; Donnarieix, D; Veyre, A; Verrelle, P;
Indirizzi:
Ctr Jean Perrin, Dept Radiotherapie, Unite Radiobiol, F-63011 Clermont Ferrand 1, France Ctr Jean Perrin Clermont Ferrand France 1 011 Clermont Ferrand 1, France INSERM, U484, F-63011 Clermont Ferrand, France INSERM Clermont Ferrand France F-63011 F-63011 Clermont Ferrand, France Fac Med, Lab Cytogenet, F-63000 Clermont Ferrand, France Fac Med ClermontFerrand France F-63000 F-63000 Clermont Ferrand, France CNRS, IN2P3, Phys Corpusculaire Lab, Aubiere, France CNRS Aubiere France NRS, IN2P3, Phys Corpusculaire Lab, Aubiere, France Etab Tech Cent Armement, F-94110 Arcueil, France Etab Tech Cent Armement Arcueil France F-94110 , F-94110 Arcueil, France Ctr Republ, F-63023 Clermont Ferrand, France Ctr Republ Clermont FerrandFrance F-63023 3023 Clermont Ferrand, France Ctr Jean Perrin, Unite Biostat, F-63011 Clermont Ferrand, France Ctr Jean Perrin Clermont Ferrand France F-63011 Clermont Ferrand, France
Titolo Testata:
RADIATION RESEARCH
fascicolo: 4, volume: 154, anno: 2000,
pagine: 406 - 411
SICI:
0033-7587(200010)154:4<406:EOLNAA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
RADIATION; RBE; TRANSFORMATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Dionet, C Ctr Jean Perrin, Dept Radiotherapie, Unite Radiobiol, BP 392,58 Rue Montalembert, F-63011 Clermont Ferrand 1, France Ctr Jean Perrin BP 392,58 Rue Montalembert Clermont Ferrand France 1
Citazione:
C. Dionet et al., "Effects of low-dose neutrons applied at reduced dose rate on human melanoma cells", RADIAT RES, 154(4), 2000, pp. 406-411

Abstract

Human melanoma cells that are resistant to gamma rays were irradiated with14 MeV neutrons given at low doses ranging from 5 cGy to 1.12 Gy at a verylow dose rate of 0.8 mGy min(-1) or a moderate dose rate of 40 mGy min(-1). The biological effects of neutrons were studied by two different methods:a cell survival assay after a 14-day incubation and an analysis of chromosomal aberrations in metaphases collected 20 h after irradiation. Unusual features of the survival curve at very low dose rate were a marked increase in cell killing at 5 cGy followed by a plateau for survival from 10 to 32.5 cGy. The levels of induced chromosomal aberrations showed a similar increase for both dose rates at 7.5 cGy and the existence of a plateau at the verylow dose rate from 15 to 30 cGy. The existence of a plateau suggests that a repair process after low-dose neutrons might be induced after a thresholddose of 5-7.5 cGy which compensates for induced damage from doses as high as 32.5 cGy. These findings may be of interest for understanding the relative biological effectiveness of neutrons and the effects of environmental low-dose irradiation. (C) 2000 by Radiation Research Society.

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Documento generato il 02/12/20 alle ore 14:29:50