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Titolo:
Replication linkage study for prostate cancer susceptibility genes
Autore:
Suarez, BK; Lin, J; Witte, JS; Conti, DV; Resnick, MI; Klein, EA; Burmester, JK; Vaske, DA; Banerjee, TK; Catalona, WJ;
Indirizzi:
Washington Univ, Sch Med, Div Urol Surg, St Louis, MO 63110 USA WashingtonUniv St Louis MO USA 63110 v Urol Surg, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA WashingtonUniv St Louis MO USA 63110 pt Psychiat, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Genet, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 Dept Genet, St Louis, MO 63110 USA Case Western Reserve Univ, Dept Epidemiol & Biostat, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA Case Western Reserve Univ, Dept Urol, Cleveland, OH 44106 USA Case WesternReserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA Univ Hosp Cleveland, Cleveland, OH 44106 USA Univ Hosp Cleveland Cleveland OH USA 44106 eland, Cleveland, OH 44106 USA Cleveland Clin Fdn, Dept Urol, Cleveland, OH 44195 USA Cleveland Clin FdnCleveland OH USA 44195 t Urol, Cleveland, OH 44195 USA Marshfield Med Res & Educ Fdn, Ctr Med Genet, Marshfield, WI 54449 USA Marshfield Med Res & Educ Fdn Marshfield WI USA 54449 field, WI 54449 USA Pioneer Hi Bred Int Inc, Trait & Technol Dev, Johnston, IA USA Pioneer Hi Bred Int Inc Johnston IA USA & Technol Dev, Johnston, IA USA Marshfield Clin, Dept Hematol Oncol, Marshfield, WI USA Marshfield Clin Marshfield WI USA Dept Hematol Oncol, Marshfield, WI USA Washington Univ, Sch Med, Div Urol Surg, St Louis, MO 63110 USA WashingtonUniv St Louis MO USA 63110 v Urol Surg, St Louis, MO 63110 USA
Titolo Testata:
PROSTATE
fascicolo: 2, volume: 45, anno: 2000,
pagine: 106 - 114
SICI:
0270-4137(20001001)45:2<106:RLSFPC>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHROMOSOME 1Q42.2-43; DOMINANT INHERITANCE; HIGH-RISK; FAMILIES; LOCUS; 1Q; SUPPORT; 1Q24-25; GENOME; HPC1;
Keywords:
prostate cancer; linkage analysis; chromosome 1; chromosome 16; replication;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Catalona, WJ Washington Univ, Sch Med, Div Urol Surg, Campus Box 8242,660 S Euclid, St Louis, MO 63110 USA Washington Univ Campus Box 8242,660 S Euclid St Louis MO USA 63110
Citazione:
B.K. Suarez et al., "Replication linkage study for prostate cancer susceptibility genes", PROSTATE, 45(2), 2000, pp. 106-114

Abstract

BACKGROUND. Since the publication of the first genome screen for prostate cancer (CaP) 5 years ago, over a dozen linkage studies have appeared. Most attention has been directed to chromosome 1, where two separate regions have been identified as harboring a prostate cancer susceptibility locus: HPC1in the 1q24-25 interval and PCaP in the 1q42.2-43 interval. Linkage analysis of chromosome 16 has also provided evidence of harboring two loci predisposing to CaP. METHODS. We report on a replication linkage study of chromosomes 1 and 16 in 45 new and 4 expanded multiplex CaP families. Multipoint Z-scores were obtained for 30 highly polymorphic short-sequence tandem repeat markers spanning chromosome 1, and 22 markers spanning chromosome 16. RESULTS. The replication sample gave no evidence for a CaP susceptibility locus in the 1q24-25 interval and equivocal evidence for such a locus at 1q42.2-43. With respect to chromosome 16, positive Z-scores were obtained over a contiguous interval covering the entire p arm and the proximal half of the q arm. CONCLUSIONS. The linkage analysis of our replication sample does not support the existence of HPC1, and the evidence for the existence of PCaP remains equivocal. Evidence of a susceptibility locus on 16p remains strong, but the evidence for a susceptibility locus on 16q is weakened. Prostate 45:106-114, 2000. (C) 2000 Wiley-Liss, Inc.

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Documento generato il 27/09/20 alle ore 00:08:56