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Titolo:
Platelet secretion during clot retraction
Autore:
White, JG;
Indirizzi:
Univ Minnesota, Sch Med, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 Pathol, Minneapolis, MN 55455 USA Univ Minnesota, Sch Med, Dept Pediat, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 Pediat, Minneapolis, MN 55455 USA
Titolo Testata:
PLATELETS
fascicolo: 6, volume: 11, anno: 2000,
pagine: 331 - 343
SICI:
0953-7104(200009)11:6<331:PSDCR>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-BLOOD PLATELETS; ALPHA-GRANULES; EXOCYTOSIS; SUBSTITUTION; ACTIVATION; PATHWAY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: White, JG Univ Minnesota, Sch Med, Dept Lab Med & Pathol, UMHC Box 490,420Delaware St SE, Minneapolis, MN 55455 USA Univ Minnesota UMHC Box 490,420 Delaware St SE Minneapolis MN USA 55455
Citazione:
J.G. White, "Platelet secretion during clot retraction", PLATELETS, 11(6), 2000, pp. 331-343

Abstract

The precise route serving as the pathway for extrusion of products contained in platelet storage organelles following cell activation has been controversial for many years. Some workers believe that the granules and dense bodies fuse together to form secretion vacuoles that move to the exposed cellsurface, fuse with it and extrude contained products to the outside. Others suggest that the organelles fuse with channels of the open canalicular system (OCS) and deposit their contents which are subsequently secreted to the exterior. The controversy has been difficult to resolve because nearly all workers have used platelets in suspension to arrive at diverse conclusions. The present study has used ethylenediamine tetracetic acid (EDTA)-treated platelets and isometric clot retraction as a model system, and either polylysine or tannic acid to define the pathway used for secretion. Results indicate that secretion takes place in EDTA platelets under isometric tensionby fusion of granules to OCS channels and passage of products through these conduits to the cell exterior. There is no evidence to suggest the organelles form secretion vacuoles or extrude their products by fusion with the inside of the exposed surface membrane.

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Documento generato il 25/01/20 alle ore 09:29:20