Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Failure of neonatal clomipramine treatment to alter forced swim immobility: chronic treadmill or activity-wheel running and imipramine
Autore:
Yoo, HS; Bunnell, BN; Crabbe, JB; Kalish, LR; Dishman, RK;
Indirizzi:
Univ Georgia, Ramsey Student Ctr, Dept Exercise Sci, Athens, GA 30602 USA Univ Georgia Athens GA USA 30602 Dept Exercise Sci, Athens, GA 30602 USA Univ Georgia, Ramsey Student Ctr, Dept Psychol, Athens, GA 30602 USA Univ Georgia Athens GA USA 30602 Ctr, Dept Psychol, Athens, GA 30602 USA
Titolo Testata:
PHYSIOLOGY & BEHAVIOR
fascicolo: 3-4, volume: 70, anno: 2000,
pagine: 407 - 411
SICI:
0031-9384(200008/09)70:3-4<407:FONCTT>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN REUPTAKE INHIBITOR; BEHAVIORAL DESPAIR TEST; ANIMAL-MODEL; ENDOGENOUS-DEPRESSION; BRAIN NOREPINEPHRINE; ANTIDEPRESSANT DRUGS; LEARNED IMMOBILITY; NEURAL ADAPTATION; RATS; TRYPTOPHAN;
Keywords:
exercise; depression; Porsolt swim test; rat model;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Dishman, RK Univ Georgia, Ramsey Student Ctr, Dept Exercise Sci, 300 RiverRd, Athens,GA 30602 USA Univ Georgia 300 River Rd Athens GA USA 30602 ens,GA 30602 USA
Citazione:
H.S. Yoo et al., "Failure of neonatal clomipramine treatment to alter forced swim immobility: chronic treadmill or activity-wheel running and imipramine", PHYSL BEHAV, 70(3-4), 2000, pp. 407-411

Abstract

We examined whether chronic running on a treadmill or activity wheel wouldattenuate the increased swim immobility that has been reported after neonatal clomipramine (CLI) treatment. Male Sprague-Dawley pups (N = 60) were injected with the monoamine reuptake inhibitor clomipramine hydrochloride (40mg/kg per day i.p.) from 8 to 21 days of age. Another group (N = 12) received saline vehicle. At age 4 weeks, the CLI pups were randomly assigned to experimental conditions: (1) sedentary; (2) 24-h access to an activity wheel; (3) sedentary that received the antidepressant drug imipramine hydrochloride (10 mg/kg twice daily) during the last 10 days of the experiment; (4) activity wheel + imipramine; (5) treadmill running (30 m/min for 1 h at 0 degrees incline, 6 days/week). At age 16 weeks, rats underwent the Porsolt swim test 48 h after the last imipramine injection and/or the last exercise session. The increase in swim immobility among CLI-treated rats was small tone quarter of SD) and not statistically significant (p > 0.10). The results are not consistent with our previous finding of antidepressant-like effects of activity-wheel running based on brain noradrenergic adaptations and enhanced male copulatory performance after neonatal CLI treatment. The lack of change in swim performance after clomipramine questions the generalizability of the CLI model of depression and the validity of the forced swim test as a behavioral measure of depression when it is used after neonatal CLI injection or chronic activity-wheel running. (C) 2000 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:35:35