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Titolo:
Effect of D-002 on gastric mucus composition in ethanol-induced ulcer
Autore:
Carbajal, D; Molina, V; Noa, M; Valdes, S; Arruzazabala, ML; Aguilar, C; Mas, R;
Indirizzi:
Natl Ctr Sci Res, Ctr Nat Prod, Dept Pharmacol, La Habana, Cuba Natl Ctr Sci Res La Habana Cuba t Prod, Dept Pharmacol, La Habana, Cuba
Titolo Testata:
PHARMACOLOGICAL RESEARCH
fascicolo: 4, volume: 42, anno: 2000,
pagine: 329 - 332
SICI:
1043-6618(200010)42:4<329:EODOGM>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
ZINC ACEXAMATE; MECHANISM; BEESWAX; RAT;
Keywords:
D-002; beeswax; aliphatic alcohol; gastric ulcer; mucus composition;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Carbajal, D Natl Ctr Sci Res, Ctr Nat Prod, Dept Pharmacol, Ciudad Habana,La Habana, Cuba Natl Ctr Sci Res Ciudad Habana La Habana Cuba a Habana, Cuba
Citazione:
D. Carbajal et al., "Effect of D-002 on gastric mucus composition in ethanol-induced ulcer", PHARMAC RES, 42(4), 2000, pp. 329-332

Abstract

This study was designed to determine the effect of D-002, a natural product isolated and purified from beeswax (Apis mellifera), on gastric mucus composition on ethanol-induced ulcer in rats. The morphology of the lesions was analysed histologically, and morphometric analysis of gastric-gland content in total glycoprotein and sulphated macromolecules were done. Oral pretreatment with D-002 at 5 and 25 mg kg(-1) 1 before oral administration of ethanol at 60%, produced a significant increase in the amount of gastric mucus and total protein. The histomorphometric evaluation of the gastric damageat the same doses showed a significant increase in neutral glycoproteins and sulfated macromolecules. It is concluded that enhancement of the quantity and quality of the mucus could partly explain the gastroprotective effectof D-002. (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 11:26:09