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Titolo:
Nociceptin differentially affects morphine-induced dopamine release from the nucleus accumbens and nucleus caudate in rats
Autore:
Di Giannuario, A; Pieretti, S;
Indirizzi:
Ist Super Sanita, Farmacol Lab, I-00161 Rome, Italy Ist Super Sanita Rome Italy I-00161 a, Farmacol Lab, I-00161 Rome, Italy
Titolo Testata:
PEPTIDES
fascicolo: 7, volume: 21, anno: 2000,
pagine: 1125 - 1130
SICI:
0196-9781(200007)21:7<1125:NDAMDR>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRAL TEGMENTAL AREA; FREELY MOVING RATS; ORPHAN OPIOID RECEPTOR; NEURONS IN-VITRO; ORL(1) RECEPTOR; MESOLIMBIC DOPAMINE; ENDOGENOUS LIGAND; INVIVO MICRODIALYSIS; DORSAL CAUDATE; FQ;
Keywords:
nociceptin; orphanin; dopamine; striatum; accumbens; caudate; microdialysis; rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Di Giannuario, A Ist Super Sanita, Farmacol Lab, Viale Regina Elena 299, I-00161 Rome, Italy Ist Super Sanita Viale Regina Elena 299 Rome Italy I-00161
Citazione:
A. Di Giannuario e S. Pieretti, "Nociceptin differentially affects morphine-induced dopamine release from the nucleus accumbens and nucleus caudate in rats", PEPTIDES, 21(7), 2000, pp. 1125-1130

Abstract

The effects induced by nociceptin on morphine-induced release of dopamine (DA), 3,4-dihydroxyphenilacetic acid (DOPAC) and homovanillic acid (HVA) inthe nucleus accumbens and nucleus caudate were studied in rats by microdialysis with electrochemical detection. Nociceptin administered intracerebroventricularly (i.c.v.) at doses of 2, 5 and 10 nmol/rat changed neither DA nor metabolites release in the shell of the nucleus accumbens or in the nucleus caudate. Morphine administered intraperitoneally (i.p. ) (2, 5, and 10 mg/kg) increased DA and metabolites release more in the shell of the nucleusaccumbens than in the nucleus caudate. When nociceptin (5 or 10 nmol) was administered 15 min before morphine (5 or 10 mg/kg), it significantly reduced morphine-induced DA and metabolites release in the shell of the nucleus accumbens, whereas only a slight, nonsignificant reduction was observed in the nucleus caudate. Our data indicate that nociceptin may regulate the stimulating action associated with morphine-induced DA release more in the nucleus accumbens than in the nucleus caudate, and are consistent with recent observations that nociceptin reversed ethanol- and morphine-induced conditioned place preference. Therefore, the nociceptin-induced reduction of DA release stimulated by morphine in the nucleus accumbens, and the results obtained with nociceptin in the conditioned place preference procedure suggest a role for nociceptin in the modulation of the behavioral and neurochemicaleffects of abuse drugs. (C) 2000 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 22:16:11