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Titolo:
Effects of an antisense oligonucleotide to pronociceptin and long-term prevention of morphine actions by nociceptin
Autore:
Candeletti, S; Ferri, S;
Indirizzi:
Univ Bologna, Dept Pharmacol, I-40126 Bologna, Italy Univ Bologna Bologna Italy I-40126 ept Pharmacol, I-40126 Bologna, Italy
Titolo Testata:
PEPTIDES
fascicolo: 7, volume: 21, anno: 2000,
pagine: 1119 - 1124
SICI:
0196-9781(200007)21:7<1119:EOAAOT>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; DORSAL HORN NEURONS; RAT SPINAL-CORD; ORPHANIN-FQ; ORL1 RECEPTOR; MESSENGER-RNA; IN-VITRO; SYNAPTIC TRANSMISSION; TISSUE DISTRIBUTION; CONSCIOUS MICE;
Keywords:
nociceptin; morphine; antisense oligodeoxynucleotide; tail-flick; body temperature; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Candeletti, S Univ Bologna, Dept Pharmacol, Irnerio 48, I-40126 Bologna, Italy Univ Bologna Irnerio 48 Bologna Italy I-40126 ologna, Italy
Citazione:
S. Candeletti e S. Ferri, "Effects of an antisense oligonucleotide to pronociceptin and long-term prevention of morphine actions by nociceptin", PEPTIDES, 21(7), 2000, pp. 1119-1124

Abstract

To further characterize the anti-opioid action of the neuropeptide nociceptin, we examined the effects of the repeated intracerebroventricular (i.c.v.) treatment (once daily for 4 days) with an antisense oligodeoxynucleotidecomplementary to pronociceptin mRNA, in the rat. We also investigated possible changes of the antinociceptive and hyperthermic effects induced by thei.c.v. administration of morphine, in rats i.c.v. pretreated with nociceptin 3 h before. The pretreatment with the antisense oligodeoxynucleotide, but not with a mismatched sequence (used as a control), caused an increase inspontaneous locomotor activity and produced a potentiation of the antinociceptive effect of a submaximal dose of i.c.v. morphine (1 mu g/rat). The i.c.v. pretreatment with nociceptin (2 nmol/rat, 3 h before) prevented both the antinociceptive and the hyperthermic effects of morphine (10 mu g/rat i.c.v.). These results strengthen the hypothesis of an anti-opioid action of nociceptin at supraspinal level and suggest that the neuropeptide may exertlong-term modulatory effects. (C) 2000 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:32:59