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Titolo:
Role of nociceptin systems in learning and memory
Autore:
Noda, Y; Mamiya, T; Manabe, T; Nishi, M; Takeshima, H; Nabeshima, T;
Indirizzi:
Nagoya Univ, Grad Sch Med, Dept Neuropsychopharmacol, Showa Ku, Nagoya, Aichi 4668560, Japan Nagoya Univ Nagoya Aichi Japan 4668560 a Ku, Nagoya, Aichi 4668560, Japan Nagoya Univ, Grad Sch Med, Hosp Pharm, Showa Ku, Nagoya, Aichi 4668560, Japan Nagoya Univ Nagoya Aichi Japan 4668560 a Ku, Nagoya, Aichi 4668560, Japan Kobe Univ, Sch Med, Dept Physiol, Chuo Ku, Kobe, Hyogo 6500017, Japan KobeUniv Kobe Hyogo Japan 6500017 l, Chuo Ku, Kobe, Hyogo 6500017, Japan Kurume Univ, Inst Life Sci, Div Cell Biol, Fukuoka 8390861, Japan Kurume Univ Fukuoka Japan 8390861 Div Cell Biol, Fukuoka 8390861, Japan
Titolo Testata:
PEPTIDES
fascicolo: 7, volume: 21, anno: 2000,
pagine: 1063 - 1069
SICI:
0196-9781(200007)21:7<1063:RONSIL>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; INHIBITS SYNAPTIC TRANSMISSION; PROTEIN-COUPLED RECEPTOR; HIPPOCAMPAL CA1 REGION; KAPPA-OPIOID RECEPTOR; ORPHANIN-FQ; NALOXONE BENZOYLHYDRAZONE; MICE LACKING; TISSUE DISTRIBUTION; MOLECULAR-CLONING;
Keywords:
nociceptin (ORL-1) receptor; knockout mice; learning and memory; kappa(3)-opioid receptor; NalBzoH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Nabeshima, T Nagoya Univ, Grad Sch Med, Dept Neuropsychopharmacol, Showa Ku, 65 TsurumaCho, Nagoya, Aichi 4668560, Japan Nagoya Univ 65 Tsuruma Cho Nagoya Aichi Japan 4668560 , Japan
Citazione:
Y. Noda et al., "Role of nociceptin systems in learning and memory", PEPTIDES, 21(7), 2000, pp. 1063-1069

Abstract

This article summarizes our recent finding that the nociceptin system is involved in the regulation of learning and memory. The nociceptin-knockout mice show greater learning ability in the water maze task, an enhanced latent learning in the water finding task, better memory in the passive avoidance task, and further, larger long-term potentiation in the hippocampal CA1 region than wild-type mice. Nociceptin itself induces an impairment of passive avoidance task in wild-type mice, which is reversed by naloxone benzoylhydrazone (NalBzoH). Thus, the nociceptin system seems to play negative roles in learning and memory, and NalBzoH may act as a potent antagonist for the nociceptin receptor. (C) 2000 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 04:53:55