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Titolo:
Orphanin FQ/nociceptin: a novel neuromodulator of gastrointestinal function?
Autore:
Osinski, MA; Brown, DR;
Indirizzi:
Univ Minnesota, Coll Vet Med, Dept Vet Pathobiol, Pharmacol Sect, St Paul,MN 55108 USA Univ Minnesota St Paul MN USA 55108 Pharmacol Sect, St Paul,MN 55108 USA Univ Wisconsin, Sch Med, Dept Med, Gastroenterol Sect, Madison, WI 53792 USA Univ Wisconsin Madison WI USA 53792 roenterol Sect, Madison, WI 53792 USA
Titolo Testata:
PEPTIDES
fascicolo: 7, volume: 21, anno: 2000,
pagine: 999 - 1005
SICI:
0196-9781(200007)21:7<999:OFANNO>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENTERIC NERVOUS-SYSTEM; MOUSE VAS-DEFERENS; NOCICEPTIN RECEPTOR; TISSUE DISTRIBUTION; OPIOID RECEPTOR; OPIATE RECEPTOR; ORL1 RECEPTOR; FQ NOCICEPTIN; IN-VITRO; RAT;
Keywords:
enteric nervous system; opioid; constipation; diarrhea; anion secretion; peristalsis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Brown, DR Univ Minnesota, Coll Vet Med, Dept Vet Pathobiol, Pharmacol Sect, 1988 Fitch Ave, St Paul, MN 55108 USA Univ Minnesota 1988 Fitch Ave St Paul MN USA 55108 MN 55108 USA
Citazione:
M.A. Osinski e D.R. Brown, "Orphanin FQ/nociceptin: a novel neuromodulator of gastrointestinal function?", PEPTIDES, 21(7), 2000, pp. 999-1005

Abstract

Orphanin FQ/nociceptin (OFQ/N) has been immunohistochemically localized inthe rat enteric nervous system, and mRNA signals for its precursor (i.e. prepro-OFQ/-N) and cognate receptor ORL-1 are expressed in the intestinal tract. OFQ/N inhibits neurogenic contractions in a variety of stomach and small intestine preparations in vitro, but contracts rodent colon. In vivo, itacts at peripheral and central nervous system sites to stimulate or inhibit mechanical activity in the stomach and colon, respectively. Thus, OFQ/N acts as a neuromodulator of gastrointestinal motility and may have additional roles in regulation of intestinal blood flow, active ion transport, and immunity. (C) 2000 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 20:29:01