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Titolo:
Cellular neurophysiological actions of nociceptin/orphanin FQ
Autore:
Moran, TD; Abdulla, FA; Smith, PA;
Indirizzi:
Univ Alberta, Div Neurosci, Edmonton, AB T6G 2H7, Canada Univ Alberta Edmonton AB Canada T6G 2H7 sci, Edmonton, AB T6G 2H7, Canada Univ Alberta, Dept Pharmacol, Edmonton, AB T6G 2H7, Canada Univ Alberta Edmonton AB Canada T6G 2H7 col, Edmonton, AB T6G 2H7, Canada Tennessee State Univ, Dept Phys Therapy, Nashville, TN 37290 USA TennesseeState Univ Nashville TN USA 37290 rapy, Nashville, TN 37290 USA
Titolo Testata:
PEPTIDES
fascicolo: 7, volume: 21, anno: 2000,
pagine: 969 - 976
SICI:
0196-9781(200007)21:7<969:CNAONF>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; DORSAL HORN NEURONS; SUBSTANTIA-GELATINOSA NEURONS; RAT SPINAL-CORD; ROOT GANGLION NEURONS; MU-OPIOID RECEPTORS; INHIBITS SYNAPTIC TRANSMISSION; ROSTRAL VENTROLATERAL MEDULLA; PERIAQUEDUCTAL GREY NEURONS; TRIGEMINAL-NUCLEUS-CAUDALIS;
Keywords:
analgesic; calcium channel; dorsal root ganglion; dorsal horn; morphine; neuropathic pain; nociceptin; opioid; orphan opioid-like receptor; potassium channel; substantia gelatinosa;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
85
Recensione:
Indirizzi per estratti:
Indirizzo: Smith, PA Univ Alberta, Div Neurosci, 9-75 Med Sci Bldg, Edmonton, AB T6G 2H7, Canada Univ Alberta 9-75 Med Sci Bldg Edmonton AB Canada T6G 2H7 Canada
Citazione:
T.D. Moran et al., "Cellular neurophysiological actions of nociceptin/orphanin FQ", PEPTIDES, 21(7), 2000, pp. 969-976

Abstract

Cellular actions of nociceptin/orphanin FQ (N/OFQ) resemble those of mu-, delta-, and kappa-opioids, i.e. activation of inwardly rectifying K+ conductance, inhibition of high-voltage-activated Ca2+ channel currents, and impediment of neurotransmitter release. Differences in ORL1 and mu-receptor distribution lead to: 1) more widespread actions of N/OFQ on periaqueductal gray neurons than opioids acid 2) differential effects of N/OFQ and opioids in the brainstem. Also, unlike opioids, N/OFQ inhibits T-type Ca2+ channel current in sensory neurons. Opioids and N/OFQ may modulate glutamate responses in different ways, and certain actions of N/OFQ are potentiated following nerve injury whereas those of mu-opioids are attenuated. Agonists at ORL,receptors may therefore be of clinical interest in the management of neuropathic pain. (C) 2000 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 10:02:36