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Titolo:
Orphanin FQ/Nociceptin receptor binding studies
Autore:
Dooley, CT; Houghten, RA;
Indirizzi:
Torrey Pines Inst Mol Studies, San Diego, CA 92121 USA Torrey Pines Inst Mol Studies San Diego CA USA 92121 Diego, CA 92121 USA
Titolo Testata:
PEPTIDES
fascicolo: 7, volume: 21, anno: 2000,
pagine: 949 - 960
SICI:
0196-9781(200007)21:7<949:OFRBS>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-COUPLED RECEPTOR; KAPPA-OPIOID RECEPTORS; ORL1 RECEPTOR; RAT-BRAIN; NOCICEPTIN RECEPTOR; IN-VITRO; FQ RECEPTOR; FUNCTIONAL EXPRESSION; TISSUE DISTRIBUTION; MOLECULAR-CLONING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Dooley, CT Torrey Pines Inst Mol Studies, 3550 Gen Atom Court, San Diego, CA 92121 USA Torrey Pines Inst Mol Studies 3550 Gen Atom Court San Diego CAUSA 92121
Citazione:
C.T. Dooley e R.A. Houghten, "Orphanin FQ/Nociceptin receptor binding studies", PEPTIDES, 21(7), 2000, pp. 949-960

Abstract

A review of the binding studies performed on the receptor (ORL) for Orphanin FQ/Nociceptin is presented. Binding studies have been conducted using a variety of receptor sources: cell lines expressing the cloned receptor, cell lines endogenously expressing the receptor, and brain and other tissue from several different species. Binding studies of opioids, new ligands and antagonists at the ORL receptor are briefly discussed. Saturation, competition and binding kinetic experiments, and the effects of buffer composition are reviewed. There are numerous instances of conflicting data in published reports on OFQ; the basis for these disparities is as yet undetermined. This review endeavors to compile the results and conditions employed in binding studies as an aid to current and new researchers in this field. In an attempt to explain binding disparities, we have determined that Orphanin/Nociceptin binds to glass fiber filtermats in a "specific" manner; these new data are presented. (C) 2000 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 14:08:04