Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Tissue distribution of the opioid receptor-like (ORL1) receptor
Autore:
Mollereau, C; Mouledous, L;
Indirizzi:
Inst Pharmacol & Biol Struct, F-31077 Toulouse, France Inst Pharmacol & Biol Struct Toulouse France F-31077 77 Toulouse, France
Titolo Testata:
PEPTIDES
fascicolo: 7, volume: 21, anno: 2000,
pagine: 907 - 917
SICI:
0196-9781(200007)21:7<907:TDOTOR>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
NOCICEPTIN ORPHANIN FQ; CENTRAL-NERVOUS-SYSTEM; RAT SPINAL-CORD; LONG-TERM POTENTIATION; MOUSE VAS-DEFERENS; GAMMA-S BINDING; GUINEA-PIG; ENDOGENOUS LIGAND; NUCLEUS NEURONS; MESSENGER-RNA;
Keywords:
neuropeptide; nociceptin or orphanin FQ; ORL1 receptor; G protein-coupled receptor; anatomic distribution;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
92
Recensione:
Indirizzi per estratti:
Indirizzo: Mollereau, C Inst Pharmacol & Biol Struct, 205 Route Narbonne, F-31077 Toulouse, France Inst Pharmacol & Biol Struct 205 Route Narbonne Toulouse France F-31077
Citazione:
C. Mollereau e L. Mouledous, "Tissue distribution of the opioid receptor-like (ORL1) receptor", PEPTIDES, 21(7), 2000, pp. 907-917

Abstract

The ORL1 receptor is a G protein-coupled receptor structurally related to the opioid receptors, whose endogenous ligand is the heptadecapeptide nociceptin/orphanin FQ. In this review, data which have contributed to the mapping of the anatomic distribution of the ORL1 receptor have been collated with an emphasis on their relation to physiological functions. The ORL1 receptor is widely expressed in the central nervous system, in particular in the forebrain (cortical areas, olfactory regions, limbic structures, thalamus),throughout the brainstem (central periaqueductal gray, substantia nigra, several sensory and motor nuclei), and in both the dorsal and ventral horns of the spinal cord. Regions almost devoid of ORL1 receptors are the caudate-putamen and the cerebellum ORL1 mRNA and binding sites exhibit approximately the same distribution pattern, indicating that the ORL1 receptor is located on local neuronal circuits. The ORL1 receptor is also expressed at the periphery in smooth muscles, peripheral ganglia, and the immune system. Theanatomic distribution of ORL1 receptor suggests a broad spectrum of actionfor the nociceptin/orphanin FQ system (sensory perception, memory process,emotional behavior, etc.). (C) 2000 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 03:00:51