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Titolo:
The orphanin FQ/nociceptin gene: structure, tissue distribution of expression and functional implications obtained from knockout mice
Autore:
Reinscheid, RK; Nothacker, HP; Civelli, O;
Indirizzi:
Univ Calif Irvine, Coll Med, Dept Pharmacol, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 ept Pharmacol, Irvine, CA 92697 USA
Titolo Testata:
PEPTIDES
fascicolo: 7, volume: 21, anno: 2000,
pagine: 901 - 906
SICI:
0196-9781(200007)21:7<901:TOFGST>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; NOCICEPTIN-LIKE IMMUNOREACTIVITY; PROTEIN-COUPLED RECEPTOR; FQ RECEPTOR; MOLECULAR-CLONING; CYCLIC-AMP; DOPAMINE RELEASE; ORL1 RECEPTOR; MESSENGER-RNA; MOUSE-BRAIN;
Keywords:
neuropeptide precursor; processing; dynorphin A; gene regulation; knockout mice; analgesia; stress; anxiety;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Reinscheid, RK Univ Calif Irvine, Coll Med, Dept Pharmacol, 354 Med Surge 2, Irvine, CA 92697 USA Univ Calif Irvine 354 Med Surge 2 Irvine CA USA 92697 7 USA
Citazione:
R.K. Reinscheid et al., "The orphanin FQ/nociceptin gene: structure, tissue distribution of expression and functional implications obtained from knockout mice", PEPTIDES, 21(7), 2000, pp. 901-906

Abstract

Like other neuropeptides, orphanin FQ/nociceptin (OFQ/N) is encoded by a larger precursor protein. The cDNA for the OFQ/N precursor has been cloned from human, rat, mouse and bovine tissue demonstrating that this peptidergicsystem serves important functions that have been conserved during evolution. The structural organization of the precursor protein is similar to opioid peptide precursors, supporting the view of a common origin for the opioidsystems and the OFQ/N system. In addition to OFQ/N, the precursor may encode two other biologically active peptides. Anatomic studies have revealed high levels of expression of the OFQ/N messenger RNA in brain structures involved in sensory, emotional and cognitive processing. In particular, high levels of OFQ/N mRNA were detected in thr limbic system, underlining the stress attenuating activities that have been described as an important function of OFQ/N. Recently, mutant mice have been generated that lack: the precursor protein of OFQ/N to further define the physiological functions of the OFQ/N system. The OFQ/N-deficient mice are characterized by an increased sensitivity to stressful stimuli and a lack of habituation to chronic and repeated stress. This review will summarize recent findings on the molecular biology of the OFQ/N precursor and relate it to possible physiological functions of this newly discovered neuropeptide system. (C) 2000 Elsevier ScienceTnc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 07:13:57