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Titolo:
New perspectives on the differentiation of aplastic anemia and MDS in children
Autore:
Ohara, A;
Indirizzi:
Toho Univ, Sch Med, Dept Pediat, Ota Ku, Tokyo 1438541, Japan Toho Univ Tokyo Japan 1438541 Dept Pediat, Ota Ku, Tokyo 1438541, Japan
Titolo Testata:
PEDIATRIC PATHOLOGY & MOLECULAR MEDICINE
fascicolo: 4, volume: 19, anno: 2000,
pagine: 261 - 267
SICI:
1522-7952(200007/08)19:4<261:NPOTDO>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYELODYSPLASTIC SYNDROMES; CYTOGENETIC ABNORMALITIES; ANTILYMPHOCYTE GLOBULIN; ANTITHYMOCYTE GLOBULIN; G-CSF; LEUKEMIA; CLASSIFICATION; CYCLOSPORINE; PROPOSALS;
Keywords:
aplastic anemia; myelodysplastic syndrome;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Ohara, A Toho Univ, Sch Med, Dept Pediat, Ota Ku, 6-11-1 Omori Nishi, Tokyo 1438541, Japan Toho Univ 6-11-1 Omori Nishi Tokyo Japan 1438541 1438541, Japan
Citazione:
A. Ohara, "New perspectives on the differentiation of aplastic anemia and MDS in children", PEDIAT PATH, 19(4), 2000, pp. 261-267

Abstract

Due to recent advances in immunosuppressive therapy, the prognosis for aplastic anemia (AA) has improved dramatically. As more patients with this disease have been surviving longer, the number of AA patients who develop myelodysplastic syndrome (MDS) or leukemia has increased. However, it is unclear whether the development of this type of late clonal disorder is related to a particular therapy, and whether hypoplastic MDS can be differentiated from AA at diagnosis. Although there are no definitive answers to these questions, some forms of AA and MDS are likely within the same spectrum of disease. Thus, when treating AA, it is essential to evaluate various clinical and laboratory information, including cell morphology and chromosomal aberration. This paper discusses acute myelocytic leukemia (AML) and MDS in children diagnosed as having AA, and it presents problems associated with the diagnosis of this disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:33:38