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Titolo:
Antimalarial drug development and new targets
Autore:
Macreadie, I; Ginsburg, H; Sirawaraporn, W; Tilley, L;
Indirizzi:
Biomol Res Inst, Parkville, Vic 3052, Australia Biomol Res Inst ParkvilleVic Australia 3052 rkville, Vic 3052, Australia Hebrew Univ Jerusalem, Dept Biol Chem, IL-91904 Jerusalem, Israel Hebrew Univ Jerusalem Jerusalem Israel IL-91904 -91904 Jerusalem, Israel Mahidol Univ, Fac Sci, Dept Biochem, Bangkok 10400, Thailand Mahidol UnivBangkok Thailand 10400 ept Biochem, Bangkok 10400, Thailand La Trobe Univ, Dept Biochem, Bundoora, Vic 3083, Australia La Trobe Univ Bundoora Vic Australia 3083 , Bundoora, Vic 3083, Australia
Titolo Testata:
PARASITOLOGY TODAY
fascicolo: 10, volume: 16, anno: 2000,
pagine: 438 - 444
SICI:
0169-4758(200010)16:10<438:ADDANT>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARASITE PLASMODIUM-FALCIPARUM; MALARIA PARASITE; QUINOLINE ANTIMALARIALS; DIHYDROFOLATE-REDUCTASE; FERRIPROTOPORPHYRIN-IX; CHLOROQUINE SENSITIVITY; HEMATIN POLYMERIZATION; INHIBITION; RESISTANCE; HEME;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Macreadie, I Biomol Res Inst, 343 Royal Parade, Parkville, Vic 3052, Australia Biomol Res Inst 343 Royal Parade Parkville Vic Australia 3052
Citazione:
I. Macreadie et al., "Antimalarial drug development and new targets", PARASIT TOD, 16(10), 2000, pp. 438-444

Abstract

The Molecular Approaches to Malaria (MAM2000) conference, Lorne, Australia, 2-5 February 2000, brought together world-class malaria research scientists. The development of new, tools and technologies - transfection, DNA microarrays and proteomic analysis - and the availability of DNA sequences generated by the Malaria Genome Project, along with more classic approaches, have facilitated the identification of novel drug targets, the development ofnew antimalarials and the generation of a deeper understanding of the molecular mechanism(s) of drug resistance in malaria. It is hoped that combinations of these technologies could lead to strategies that enable the development of effective, efficient ann affordable new drugs to overcome drug-resistant malaria, ns discussed at MAM2000 and outlined here by Ian Macreadie and colleagues.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 19:49:26