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Titolo:
An efficient chiral moderator prepared from inexpensive (+)3-carene: Synthesis of the HIV-1 non-nucleoside reverse transcriptase inhibitor DPC 963
Autore:
Kauffman, GS; Harris, GD; Dorow, RL; Stone, BRP; Parsons, RL; Pesti, JA; Magnus, NA; Fortunak, JM; Confalone, PN; Nugent, WA;
Indirizzi:
Dupont Merck Pharmaceut Co, Chem Proc R&D, Chambers Works, Deepwater, NJ 08023 USA Dupont Merck Pharmaceut Co Deepwater NJ USA 08023 Deepwater, NJ 08023 USA
Titolo Testata:
ORGANIC LETTERS
fascicolo: 20, volume: 2, anno: 2000,
pagine: 3119 - 3121
SICI:
1523-7060(20001005)2:20<3119:AECMPF>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNODEFICIENCY-VIRUS TYPE-1; ENANTIOSELECTIVE ADDITION; EFAVIRENZ SUSTIVA(TM); ASYMMETRIC-SYNTHESIS; ACETYLIDE; KETONE; L-743,726; ANALOGS; DMP-266;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Nugent, WA Dupont Merck Pharmaceut Co, Chem Proc R&D, Chambers Works, PRF Bldg S1, Deepwater, NJ 08023 USA Dupont Merck Pharmaceut Co PRF Bldg S1 Deepwater NJ USA 08023 A
Citazione:
G.S. Kauffman et al., "An efficient chiral moderator prepared from inexpensive (+)3-carene: Synthesis of the HIV-1 non-nucleoside reverse transcriptase inhibitor DPC 963", ORG LETT, 2(20), 2000, pp. 3119-3121

Abstract

[GRAPHICS]The beta-amino alcohol 4 beta-morpholinocaran-3 alpha-ol is prepared by addition of morpholine to alpha-3,4-epoxycarane utilizing anhydrous magnesiumbromide as Lewis acid promoter. The enantiopure amino alcohol is uniquely effective as a chiral moderator for the addition of lithium cyclopropylacetylide to an unprotected N-acylketimine. This reaction provides an efficientroute to the second generation NNRTI drug candidate DPC 963.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 21:52:48