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Titolo:
Angiogenic interactions of vascular endothelial growth factor, of thymidine phosphorylase, and of p53 protein expression in locally advanced gastric cancer
Autore:
Giatromanolaki, A; Koukourakis, MI; Stathopoulos, GP; Kapsoritakis, A; Paspatis, G; Kakolyris, S; Sivridis, E; Georgoulias, V; Harris, AL; Gatter, KC;
Indirizzi:
Tumour & Angiogenesis Res Grp, Iraklion 71306, Crete, Greece Tumour & Angiogenesis Res Grp Iraklion Crete Greece 71306 , Crete, Greece Democritus Univ Thrace, Dept Pathol, Xanthi, Greece Democritus Univ Thrace Xanthi Greece hrace, Dept Pathol, Xanthi, Greece Univ Thessalia, Sch Med, Dept Radiotherapy & Oncol, Larisa, Greece Univ Thessalia Larisa Greece Dept Radiotherapy & Oncol, Larisa, Greece Venizelion Gen Hosp, Dept Gastroenterol, Crete, Greece Venizelion Gen Hosp Crete Greece osp, Dept Gastroenterol, Crete, Greece Univ Athens, Ippocrat Hosp, Med Div 2, Athens, Greece Univ Athens AthensGreece ens, Ippocrat Hosp, Med Div 2, Athens, Greece Oxford Radcliffe Hosp, Dept Cellular Sci, Oxford, England Oxford RadcliffeHosp Oxford England Dept Cellular Sci, Oxford, England Oxford Radcliffe Hosp, Imperial Canc Res Fund, Med Oncol Unit, Oxford, England Oxford Radcliffe Hosp Oxford England d, Med Oncol Unit, Oxford, England
Titolo Testata:
ONCOLOGY RESEARCH
fascicolo: 1, volume: 12, anno: 2000,
pagine: 33 - 41
SICI:
0965-0407(2000)12:1<33:AIOVEG>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
SQUAMOUS-CELL HEAD; HUMAN COLON-CANCER; WILD-TYPE P53; TUMOR ANGIOGENESIS; LUNG-CANCER; BREAST-CANCER; GENE-TRANSFER; NECK-CANCER; CARCINOMA; THERAPY;
Keywords:
gastric cancer; angiogenesis; p53; VEGF; thymidine phosphorylase; platelet-derived endothelial cell growth factor (PD-ECGF);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Giatromanolaki, A Tumour & Angiogenesis Res Grp, 18 Dimokratias Ave, Iraklion 71306, Crete, Greece Tumour & Angiogenesis Res Grp 18 Dimokratias Ave Iraklion Crete Greece 71306
Citazione:
A. Giatromanolaki et al., "Angiogenic interactions of vascular endothelial growth factor, of thymidine phosphorylase, and of p53 protein expression in locally advanced gastric cancer", ONCOL RES, 12(1), 2000, pp. 33-41

Abstract

The assessment of the angiogenic profile of tumors may become an importanttool as a guide for the inclusion of novel drugs and molecular therapies into the standard chemoradiotherapy policy. Several studies have shown the prognostic importance of microvessel density (MVD) and of angiogenic factor expression in operable gastric cancer. In the present study we investigated, with immunohistochemistry the MVD, the expression of vascular endothelialgrowth factor (VEGF) and of thymidine phosphorylase (TP) expression, as well as the nuclear expression of p53 protein, in a series of patients with locally advanced inoperable gastric cancer. A strong association of VEGF with TP expression was noted (P = 0.005), and tumors coexpressing these factors had a statistically higher MVD (P = 0.0001). Nuclear p53 accumulation wasalso related to a high MVD (P = 0.004); and this was independent of VEGF or TP expression. Microvessel density showed a bell-shaped association with prognosis; cases with an intermediate MVD exhibit a favorable outcome (P < 0.05). A trend of nuclear TP expression to define a group of patients with poorer prognosis was noted (P = 0.06), while none of the remaining variables showed any significant association;The immunostaining results allowed thegrouping of the ungiogenic profile in four major categories: 1) highly vascularized tumors with VEGF and/or TP expression (about 36% of cases); 2) highly angiogenic tumors with p53 nuclear accumulation and low VEGF/TP expression (7% of cases); 3) poorly vascularized tumor with low VEGF/TP and negative nuclear p53 staining (32% of cases); 4) poorly vascularized tumors withTP expression (76 of cases). Specific therapies targeting hypoxia, VEGF, or TP expression as well as p53 gene therapy have entered clinical experimentation or are already available for clinical use. Using the suggested markers more than 80% of locally advanced gastric carcinomas can be grouped in different categories according to their angiogenic profile. Such a categorization may be useful for phase III trials on novel therapies targeting the major angiogenesis-related features studied here.

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Documento generato il 09/07/20 alle ore 14:06:52