Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
CD18/CD54(+CD102), CD2/CD58 pathway-independent killing of lymphokine-activated killer (LAK) cells against glioblastoma cell lines T98G and U373MG
Autore:
Komatsu, F; Kajiwara, M;
Indirizzi:
Tokyo Med & Dent Univ, Sch Med, Blood Transfus Serv, Bunkyo Ku, Tokyo 1138519, Japan Tokyo Med & Dent Univ Tokyo Japan 1138519 unkyo Ku, Tokyo 1138519, Japan
Titolo Testata:
ONCOLOGY RESEARCH
fascicolo: 1, volume: 12, anno: 2000,
pagine: 17 - 24
SICI:
0965-0407(2000)12:1<17:CCPKOL>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLASS-I; MEDIATED CYTOTOXICITY; TARGET-CELLS; RECEPTOR; NK-92; FAS; INVOLVEMENT; LYMPHOCYTE; ANTIGENS; DEATH;
Keywords:
lymphokine-activated killer cell; adhesion molecules; tumor necrosis factor-related apoptosis-inducing; ligand (TRAIL); T98G; U373MG; NK-92;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Komatsu, F Tokyo Med & Dent Univ, Sch Med, Blood Transfus Serv, Bunkyo Ku,Yushima 1-5-45, Tokyo 1138519, Japan Tokyo Med & Dent Univ Yushima 1-5-45 Tokyo Japan 1138519 Japan
Citazione:
F. Komatsu e M. Kajiwara, "CD18/CD54(+CD102), CD2/CD58 pathway-independent killing of lymphokine-activated killer (LAK) cells against glioblastoma cell lines T98G and U373MG", ONCOL RES, 12(1), 2000, pp. 17-24

Abstract

For natural killer cell-mediated cytolysis (NK-lysis) and lymphokine-activated killer cell-mediated cytolysis (LAK-lysis), the co-stimulatory signalsof CD18/CD54(+CD102) and CD2/CD58 pathways are essential. However, in thisreport, we describe a LAK-lysis that does not depend upon these two pathways. The killed cells were glioblastoma cell lines T98G and U373MG. The LAK cells were induced from peripheral blood lymphocytes in the presence of interleukin-2. 1) The T98G and U373MG did not express CD54 or CD102, but expressed CD58. 2) However, when they were pretreated with an anti-CD58 (TS2/9),the LAK-lysis was not blocked. 3) The LAK-lysis was markedly inhibited by pretreating with Concanamycin A and slightly inhibited by treating with antitumor necrosis factor-related apoptosis-inducing ligand (anti-TRAIL) antibody. 4) Nineteen percent of the LAK cells adhered to the T98G. The adhered LAK cells killed it. But nonadherent LAK cells could not kill the T98G or U373MG but killed lymphoblastoma cell lines Raji and NALM-6. These findings suggested that this type of the LAK-lysis might not depend upon the CD18/CD54(+CD102) pathway or CD2/CD58 pathway. The effector cells that killed the T98G and U373MG might not always be the same as the effector cells that killed the other cell lines. The LAK cells contain several subsets, and one ofthe subsets might kill these two target cell lines.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 11:54:56