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Titolo:
Spatially and functionally distinct roles of the PI3-K effector pathway during NGF signaling in sympathetic neurons
Autore:
Kuruvilla, R; Ye, HH; Ginty, DD;
Indirizzi:
Johns Hopkins Univ, Sch Med, Howard Hughes Med Inst, Dept Neurosci, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 urosci, Baltimore, MD 21205 USA
Titolo Testata:
NEURON
fascicolo: 3, volume: 27, anno: 2000,
pagine: 499 - 512
SICI:
0896-6273(200009)27:3<499:SAFDRO>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE GROWTH-FACTOR; RETROGRADE AXONAL-TRANSPORT; AKT PROTEIN-KINASE; PHOSPHATIDYLINOSITOL 3-KINASE; RECEPTOR TRAFFICKING; NEUROTROPHIN RECEPTORS; SELECTIVE INHIBITOR; TYROSINE KINASE; SURVIVAL; TRKA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Ginty, DD Johns Hopkins Univ, Sch Med, Howard Hughes Med Inst, Dept Neurosci, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 ltimore, MD 21205 USA
Citazione:
R. Kuruvilla et al., "Spatially and functionally distinct roles of the PI3-K effector pathway during NGF signaling in sympathetic neurons", NEURON, 27(3), 2000, pp. 499-512

Abstract

NGF is a target-derived growth factor for developing sympathetic neurons. Here, we show that application of NGF exclusively to distal axons of sympathetic neurons leads to an increase in PI3-K signaling in both distal axons and cell bodies. In addition, there is a more critical dependence on PI3-K for survival of neurons supported by NGF acting exclusively on distal axonsas compared to neurons supported by NGF acting directly on cell bodies. Interestingly, PI3-K signaling within both cell bodies and distal axons contributes to survival of neurons. The requirement for PI3-K signaling in distal axons for survival may be explained by the finding that inhibition of PI3-K in the distal axons attenuates retrograde signaling. Therefore, a singleTrkA effector, PI3-K, has multiple roles within spatially distinct cellular locales during retrograde NGF signaling.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 14:32:20