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Titolo:
Schnurri mediates Dpp-dependent repression of brinker transcription
Autore:
Marty, T; Muller, B; Basler, K; Affolter, M;
Indirizzi:
Univ Basel, Biozentrum, Abt Zellbiol, CH-4056 Basel, Switzerland Univ Basel Basel Switzerland CH-4056 ellbiol, CH-4056 Basel, Switzerland Univ Zurich, Inst Mol Biol, CH-8057 Zurich, Switzerland Univ Zurich Zurich Switzerland CH-8057 Biol, CH-8057 Zurich, Switzerland
Titolo Testata:
NATURE CELL BIOLOGY
fascicolo: 10, volume: 2, anno: 2000,
pagine: 745 - 749
SICI:
1465-7392(200010)2:10<745:SMDROB>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
MORPHOGEN GRADIENT; DROSOPHILA EMBRYOS; PROTEIN; SEQUENCE; ENCODES; REVEALS; FAMILY; TARGET; GENES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Affolter, M Univ Basel, Biozentrum, Abt Zellbiol, Klingelbergstr 70, CH-4056 Basel, Switzerland Univ Basel Klingelbergstr 70 Basel Switzerland CH-4056 erland
Citazione:
T. Marty et al., "Schnurri mediates Dpp-dependent repression of brinker transcription", NAT CELL BI, 2(10), 2000, pp. 745-749

Abstract

Signalling by Decapentaplegic (Dpp), a member of the TGF beta superfamily of signalling molecules, controls many aspects of Drosophila development byactivating and repressing target genes. Several essential components of the Dpp signalling pathway have been identified, including the Dpp receptors Punt and Thick veins (Tkv) as well as the cytoplasmic mediators Mad and Medea, For target genes to be activated, Dpp signalling must suppress transcription of a repressor encoded by the brinker (brk) gene. Here we show that Schnurri (Shn), a large zinc-finger protein, is essential for Dpp-mediated repression of brk transcription; in contrast, Shn is not required for target-gene activation. Thus, the Dpp signalling pathway bifurcates, downstream of the signal-mediating SMAD proteins, into a Shn-dependent pathway leading to brk repression and a Shn-independent pathway leading to gene activation. The existence of several Shn-like proteins in vertebrates and the observation that Brk functions in BMP signalling in Xenopus indicates that a similar regulatory cascade may be conserved in higher organisms.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 04:01:49