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Titolo:
Inhibition of hippocampal kindling by metabotropic glutamate receptor antisense oligonucleotides
Autore:
Greenwood, RS; Fan, Z; McHugh, R; Meeker, R;
Indirizzi:
Univ N Carolina, Sch Med, Dept Neurol, Chapel Hill, NC 27599 USA Univ N Carolina Chapel Hill NC USA 27599 eurol, Chapel Hill, NC 27599 USA Univ N Carolina, Sch Med, Dept Pediat, Chapel Hill, NC 27599 USA Univ N Carolina Chapel Hill NC USA 27599 ediat, Chapel Hill, NC 27599 USA Univ N Carolina, Sch Med, Curriculum Neurobiol, Chapel Hill, NC 27599 USA Univ N Carolina Chapel Hill NC USA 27599 obiol, Chapel Hill, NC 27599 USA
Titolo Testata:
MOLECULAR AND CELLULAR NEUROSCIENCE
fascicolo: 3, volume: 16, anno: 2000,
pagine: 233 - 243
SICI:
1044-7431(200009)16:3<233:IOHKBM>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; METHYL-D-ASPARTATE; BASOLATERAL AMYGDALA NEURONS; RAT SUPRAOPTIC NUCLEUS; GROUP-I; SYNAPTIC TRANSMISSION; MESSENGER-RNA; SIGNAL TRANSDUCTION; CALCIUM CHANNELS; SEIZURE ACTIVITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
67
Recensione:
Indirizzi per estratti:
Indirizzo: Greenwood, RS Univ N Carolina, Sch Med, Dept Neurol, Chapel Hill, NC 27599USA Univ N Carolina Chapel Hill NC USA 27599 Hill, NC 27599 USA
Citazione:
R.S. Greenwood et al., "Inhibition of hippocampal kindling by metabotropic glutamate receptor antisense oligonucleotides", MOL CELL NE, 16(3), 2000, pp. 233-243

Abstract

Recent work has shown that metabotropic glutamate receptors (mGluRs) increase in response to seizure activity and can contribute significantly to theexpression and progression of partial seizures. Using the kindling model of temporal lobe seizures, we evaluated the ability of local hippocampal injections of mGluR1 antisense or mGluR3 antisense oligonucleotides to suppress receptor expression and alter hippocampal kindling. Daily antisense injections in the hippocampus resulted in a significant decrease in mGluR1 or mGluR2/3 immunoreactivity. Rats injected with mGluR3 antisense showed a briefsuppression of afterdischarge duration when compared to matched rats injected with a nonsense-oligonucleotide. Rats injected with a mGluR1 antisense oligonucleotide had a dramatic suppression of the rate of seizure progression with no significant effect on afterdischarge duration. Suppression of mGluR1 synthesis by local antisense inhibition may provide a new therapeutic approach for the control of epileptogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 23:40:50