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Titolo:
Monoselenolipoic acid may be an outstanding pharmaceutical antioxidant with direct thioredoxin-like activity
Autore:
McCarty, MF;
Indirizzi:
Pantox Labs, San Diego, CA 92109 USA Pantox Labs San Diego CA USA 92109Pantox Labs, San Diego, CA 92109 USA
Titolo Testata:
MEDICAL HYPOTHESES
fascicolo: 3, volume: 55, anno: 2000,
pagine: 185 - 186
SICI:
0306-9877(200009)55:3<185:MAMBAO>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALPHA-LIPOIC ACID; ISCHEMIA-REPERFUSION INJURY; NF-KAPPA-B; DIHYDROLIPOIC ACID; LIPOAMIDE DEHYDROGENASE; CEREBRAL-ISCHEMIA; ESCHERICHIA-COLI; VITAMIN-E; REDUCTION; PROTECTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: McCarty, MF Pantox Labs, 4622 Santa Fe St, San Diego, CA 92109 USA Pantox Labs 4622 Santa Fe St San Diego CA USA 92109 92109 USA
Citazione:
M.F. McCarty, "Monoselenolipoic acid may be an outstanding pharmaceutical antioxidant with direct thioredoxin-like activity", MED HYPOTH, 55(3), 2000, pp. 185-186

Abstract

Owing to the low pKa of its selenohydryl group, reduced monoselenolipoic acid (MSL) can be expected to be a very versatile antioxidant with direct thioredoxin-like activity. Since MSL supports the growth of lipoate-dependentbacteria, it can be anticipated that MSL will be susceptible to reversiblereduction by one or more of the enzymes that reduces lipoic acid - thus greatly potentiating MSLs utility as an antioxidant. If it is not metabolizedto release toxic free selenide, MSL may have interesting pharmaceutical potential. (C) 2000 Harcourt Publishers Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 23:54:53