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Titolo:
INVOLVEMENT OF PROGRAMMED CELL-DEATH IN MORPHOGENESIS OF THE VERTEBRATE INNER-EAR
Autore:
FEKETE DM; HOMBURGER SA; WARING MT; RIEDL AE; GARCIA LF;
Indirizzi:
PURDUE UNIV,DEPT BIOL SCI W LAFAYETTE IN 47907 BOSTON COLL,DEPT BIOL CHESTNUT HILL MA 02167
Titolo Testata:
Development
fascicolo: 12, volume: 124, anno: 1997,
pagine: 2451 - 2461
SICI:
0950-1991(1997)124:12<2451:IOPCIM>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRACHYDANIO-RERIO; CHICK-EMBRYO; BCL-2; EXPRESSION; ZEBRAFISH; FUSION;
Keywords:
VERTEBRATE; CHICK; SEMICIRCULAR CANAL; APOPTOSIS; OTOCYST; RETROVIRUS; EPITHELIAL FUSION; TUNEL; BCL-2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
D.M. Fekete et al., "INVOLVEMENT OF PROGRAMMED CELL-DEATH IN MORPHOGENESIS OF THE VERTEBRATE INNER-EAR", Development, 124(12), 1997, pp. 2451-2461

Abstract

An outstanding challenge in developmental biology is to reveal the mechanisms underlying the morphogenesis of complex organs. A striking example is the developing inner ear of the vertebrate, which acquires a precise three-dimensional arrangement of its constituent epithelial cells to form three semicircular canals, a central vestibule and a coiled cochlea (in mammals). In generating a semicircular canal, epithelialcells seem to 'disappear' from the center of each canal. This phenomenon has been variously explained as (i) transdifferentiation of epithelium into mesenchyme, (ii) absorption of cells into the expanding canal or (iii) programmed cell death. In this study, an in situ DNA-end labeling technique (the TUNEL protocol) was used to map regions of cell death during inner ear morphogenesis in the chicken embryo from embryonic days 3.5-10. Regions of cell death previously identified in vertebrate ears have been confirmed, including the ventromedial otic vesicle, the base of the endolymphatic duct and the fusion plates of the semicircular canals. New regions of cell death are also described in and around the sensory organs. Reducing normal death using retrovirus-mediated overexpression of human bcl-2 causes abnormalities in ear morphogenesis: hollowing of the center of each canal is either delayed or fails entirely. These data provide new evidence to explain the role of cell death in morphogenesis of the semicircular canals.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 05:16:32