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Titolo:
Genomic homology of the domestic ferret with cats and humans
Autore:
Cavagna, P; Menotti, A; Stanyon, R;
Indirizzi:
NCI, Mol Cytogenet Sect, Frederick, MD 21702 USA NCI Frederick MD USA 21702 I, Mol Cytogenet Sect, Frederick, MD 21702 USA Univ Genoa, Dept Expt Biol, I-16132 Genoa, Italy Univ Genoa Genoa Italy I-16132 noa, Dept Expt Biol, I-16132 Genoa, Italy Univ Genoa, Dept Anthropol Sci, Basic Res Lab, I-16132 Genoa, Italy Univ Genoa Genoa Italy I-16132 Sci, Basic Res Lab, I-16132 Genoa, Italy
Titolo Testata:
MAMMALIAN GENOME
fascicolo: 10, volume: 11, anno: 2000,
pagine: 866 - 870
SICI:
0938-8990(200010)11:10<866:GHOTDF>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
ZOO-FISH ANALYSIS; ANCESTRAL KARYOTYPE; CHROMOSOME; HYBRIDIZATION; CARNIVORES; GENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Stanyon, R NCI, Mol Cytogenet Sect, Bldg 560, Frederick, MD 21702 USA NCI Bldg 560 Frederick MD USA 21702 60, Frederick, MD 21702 USA
Citazione:
P. Cavagna et al., "Genomic homology of the domestic ferret with cats and humans", MAMM GENOME, 11(10), 2000, pp. 866-870

Abstract

We used chromosome paints from both the domestic cat and humans to directly establish chromosomal homology between the genome of these species and the domestic ferret. The chromosome painting data indicate that the ferret has a highly conserved karyotype closer to the ancestral carnivore karyotype than that of the cat. The cat chromosome paints revealed 22 homologous autosomal regions in the ferret genome: 16 ferret chromosomes were hybridized by a single cat paint, while 3 ferret chromosomes were hybridized by two catpaints. In situ hybridization combined with banding showed that ferret Chromosome (Chr) 1 = cat A2p/C2, Chr 2 = F2/C1q, and Chr 3 = A2q/D2. Five ferret chromosomes are homologous to single arms of cat chromosomes: ferret 4 =A1q, 5 = Big, 6 = Clp, 10 = Alp, and 12 = B1p. The human chromosome paintsrevealed 32 + XY homologous regions in the ferret genome: 9 ferret chromosomes were each hybridized by a single human paint, 7 by two paints, 3 by three paints. The 10 ferret chromosomes hybridized by multiple human paints produced the following associations: ferret 1 = human 19/3/21, 2 = 8q/2q, 3 = 10/7,5 = 8/4, 8 = 15/14, 9 = 10/12/22, 11 = 20/2, 12 = 8/4, 14 = 12/22/18, 18 = 19/16. We present an index of genomic diversity, Z, based on the relative number of conserved whole chromosome and chromosome segments as a preliminary statistic for rapid comparison between species. The index of diversity between human-ferret (Z = 0.812) is slightly less than human-cat (Z = 0.843). The homology data presented here allow us to transfer gene mapping data from both cats and humans to the ferret.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 12:08:52