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Titolo:
Magnetic resonance diffusion tensor imaging for characterizing diffuse andfocal white matter abnormalities in multiple sclerosis
Autore:
Bammer, R; Augustin, M; Strasser-Fuchs, S; Seifert, T; Kapeller, P; Stollberger, R; Ebner, F; Hartung, HP; Fazekas, F;
Indirizzi:
Graz Univ, Dept Neurol, A-8036 Graz, Austria Graz Univ Graz Austria A-8036 az Univ, Dept Neurol, A-8036 Graz, Austria Karl Franzens Univ Graz, Magnet Resonance Inst, Graz, Austria Karl Franzens Univ Graz Graz Austria gnet Resonance Inst, Graz, Austria Karl Franzens Univ Graz, Dept Radiol, Graz, Austria Karl Franzens Univ Graz Graz Austria v Graz, Dept Radiol, Graz, Austria
Titolo Testata:
MAGNETIC RESONANCE IN MEDICINE
fascicolo: 4, volume: 44, anno: 2000,
pagine: 583 - 591
SICI:
0740-3194(200010)44:4<583:MRDTIF>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
SELF-DIFFUSION; SPIN-ECHO; LESIONS; MRI; ANISOTROPY; WATER; BRAIN;
Keywords:
magnetic resonance imaging; brain; multiple sclerosis; diffusion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Fazekas, F Graz Univ, Dept Neurol, Auenbruggerpl 22, A-8036 Graz, Austria Graz Univ Auenbruggerpl 22 Graz Austria A-8036 6 Graz, Austria
Citazione:
R. Bammer et al., "Magnetic resonance diffusion tensor imaging for characterizing diffuse andfocal white matter abnormalities in multiple sclerosis", MAGN RES M, 44(4), 2000, pp. 583-591

Abstract

High-resolution diffusion tensor imaging (DTI) was performed in 14 patients with clinically definite multiple sclerosis (MS) and the trace of the diffusion tensor ([D]) and the fractional anisotropy (FA) were determined in normal appearing white matter (NAWM) and in different types of focal MS lesions. A small but significant increase of the [D] in NAWM compared to control white matter ((840 +/- 85) x 10(-6) mm(2)/sec vs. (812 +/- 59) x 10(-6) mm2/sec; P < 0.01) was found. In addition, there was a significant decrease in the FA of normal-appearing regions containing well-defined white matter tracts, such as the genu of the internal capsule. In non-acute lesions, the[D] of T-1-hypointense areas was significantly higher than that of T-1-isointense lesions ((1198 +/- 248) x 10(-6) mm(2)/sec vs. (1006 +/- 142) x 10(-6) mm(2)/sec; P < 0.001), and there was a corresponding inverse relation of FA. Diffusion characteristics of active lesions with different enhancement patterns were also significantly different. DTI with a phase navigated interleaved echo planar imaging technique may be used to detect abnormalitiesof isotropic and anisotropic diffusion in the NAWM and selected fiber tracts of patients with MS throughout the entire brain, and it demonstrates substantial differences between various types of focal lesions. (C) 2000 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 07:36:09