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Titolo:
Development of digestive and immunological function in neonates: role of early nutrition
Autore:
Kelly, D; Coutts, AGP;
Indirizzi:
Rowett Res Inst, Dept Intestinal Cell Biol & Immunol, Aberdeen AB21 9SB, Scotland Rowett Res Inst Aberdeen Scotland AB21 9SB , Aberdeen AB21 9SB, Scotland
Titolo Testata:
LIVESTOCK PRODUCTION SCIENCE
fascicolo: 2, volume: 66, anno: 2000,
pagine: 161 - 167
SICI:
0301-6226(200010)66:2<161:DODAIF>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD GROUP ANTIGENS; HUMAN-MILK; T-CELLS; ESCHERICHIA-COLI; IMMUNOHISTOCHEMICAL ANALYSIS; DENDRITIC CELLS; SUCKLING PIGS; EXPRESSION; LECTIN; LYMPHOCYTES;
Keywords:
intestine; development; immune system; early nutrition; environmental antigens;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Kelly, D Rowett Res Inst, Dept Intestinal Cell Biol & Immunol, Greenburn Rd, Aberdeen AB21 9SB, Scotland Rowett Res Inst Greenburn Rd Aberdeen Scotland AB21 9SB Scotland
Citazione:
D. Kelly e A.G.P. Coutts, "Development of digestive and immunological function in neonates: role of early nutrition", LIVEST PROD, 66(2), 2000, pp. 161-167

Abstract

The developing intestine undergoes morphogenesis and cytodifferentiation, events that are exquisitely regulated and highly organised, both spatially and temporally. The outermost epithelial layer of the intestine, the site of nutrient digestion and absorption, is organised into two morphological and functionally distinct compartments. Within the crypt, stem cells undergo several cycles of cell division and migrate onto the villus where they exhibit changes in phenotype and functional characteristics. Enzyme, transporter and glycosylation patterns change dramatically during the transition frombirth to adulthood. These transitions permit dietary change and adaptation, and are also important determinants of disease susceptibility. In addition to its role in nutrient uptake, the intestine represents a key innate component of intestinal defence by providing a physical barrier to the external environment. Maintenance of tight junctions and the ability to secrete mucin are critical components of its protective function. Innate immunity is particularly important to the neonate, as the active or specific arm of theimmune system is immature. In early life, the presence and processing of luminal antigen, particularly bacterial antigen, drives the expansion of intestinal epithelial and lymphoid tissues. Early nutrition is also recognisedto play a very significant role in modulating intestinal differentiation and function and in regulating immune responses to environmental antigens. (C) 2000 Published by Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 12:52:14