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Titolo:
Intestinal maturation induced by spermine in young animals
Autore:
Peulen, O; Deloyer, P; Grandfils, C; Loret, S; Dandrifosse, G;
Indirizzi:
Univ Liege, Inst Chem B6C, Dept Biochem & Gen Physiol, B-4000 Liege, Belgium Univ Liege Liege Belgium B-4000 hem & Gen Physiol, B-4000 Liege, Belgium
Titolo Testata:
LIVESTOCK PRODUCTION SCIENCE
fascicolo: 2, volume: 66, anno: 2000,
pagine: 109 - 120
SICI:
0301-6226(200010)66:2<109:IMIBSI>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT SMALL-INTESTINE; ORALLY-ADMINISTERED SPERMINE; PITUITARY-ADRENAL AXIS; CRYPT CELL FUNCTIONS; SUCKLING RATS; ORNITHINE DECARBOXYLASE; HUMAN-MILK; GASTROINTESTINAL-TRACT; DIETARY SPERMINE; INFANT FORMULAS;
Keywords:
polyamine; spermine; small intestine; maturation; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Dandrifosse, G Univ Liege, Inst Chem B6C, Dept Biochem & Gen Physiol, B-4000 Liege, Belgium Univ Liege Liege Belgium B-4000 ol, B-4000 Liege, Belgium
Citazione:
O. Peulen et al., "Intestinal maturation induced by spermine in young animals", LIVEST PROD, 66(2), 2000, pp. 109-120

Abstract

In suckling mts, it has been established that oral administration of spermine, a dietary polyamine, at appropriate doses, induces all the modifications in the digestive tract that occur at weaning, namely, (a) in the intestine: variations in the specific activities of disaccharidases and peptidases, gene expression, the level of receptors to polymeric immunoglobulins (RPIs), tissue histology, and the intestinal permeability to macromolecules; (b) maturation of the intestinal immunological system, an observation confirmed in mice; (c) an increase in the specific activity of enzymes contained in the pancreas; (d) a change in the growth rate and biochemical properties of the liver, e.g., in the synthesis of RPIs. The mechanism of spermine action is partly understood. In the intestine, two phases of events have been recorded. The first phase consists of the desquamation of the epithelium resulting from an activation of apoptosis, probably induced by the entrance of spermine into the enterocytes. The second phase concerns a hormonal cascade in which adrenocorticotrophic hormone, cytokines, bombesin and corticosterone intervene. A general hypothesis taking into account all the results obtained until now is presented as well as other observations recorded on the effect of exogenous spermine on the intestinal maturation of vertebrates other than the rat. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 00:45:24