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Titolo:
LET dependency of heavy-ion induced apoptosis in V79 cells
Autore:
Aoki, M; Furusawa, Y; Yamada, T;
Indirizzi:
Natl Inst Radiol Sci, Space & Particle Radiat Sci Res Grp, Inage Ku, Chiba2638555, Japan Natl Inst Radiol Sci Chiba Japan 2638555 , Inage Ku, Chiba2638555, Japan Chiba Univ, Grad Sch Sci & Technol Divers & Fractal Sci Diver, Inage Ku, Chiba 2638522, Japan Chiba Univ Chiba Japan 2638522 Sci Diver, Inage Ku, Chiba 2638522, Japan Cent Res Inst Elect Power Ind, Komae, Tokyo 2018511, Japan Cent Res Inst Elect Power Ind Komae Tokyo Japan 2018511 yo 2018511, Japan
Titolo Testata:
JOURNAL OF RADIATION RESEARCH
fascicolo: 2, volume: 41, anno: 2000,
pagine: 163 - 175
SICI:
0449-3060(200006)41:2<163:LDOHIA>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
RELATIVE BIOLOGICAL EFFECTIVENESS; T-LYMPHOMA CELLS; INDUCED G2 DELAY; HIGH-LET; IRRADIATION; INDUCTION; ARREST; RADIOTHERAPY; LYMPHOCYTES; EXPOSURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Aoki, M Natl Inst Radiol Sci, Space & Particle Radiat Sci Res Grp, Inage Ku, 4-9-1Anagawa, Chiba 2638555, Japan Natl Inst Radiol Sci 4-9-1 Anagawa Chiba Japan 2638555 555, Japan
Citazione:
M. Aoki et al., "LET dependency of heavy-ion induced apoptosis in V79 cells", J RADIAT R, 41(2), 2000, pp. 163-175

Abstract

We investigated the relationship between the LET values and cell death, defined as either apoptosis or loss of reproductive integrity (reproductive death), using Chinese hamster V79 cells. The cells were irradiated with X-rays or carbon-ion beams from the Heavy Ion Medical Accelerator in Chiba (HIMAC) at the National Institute of Radiological Sciences (NIRS). Apoptosis was defined based on the morphological change upon treating of cells with caffeine. The apoptotic index, the ratio of apoptotic cells to the total, after exposure to 2 Gy of X-rays was 0.043. Upon irradiation with carbon-ion beams, the index was gradually increased with increasing LET values, reachinga maximum of 0.076 at 110 keV/mu m, and then decreased to 0.054 at 237 keV/mu m. An analogous pattern of the LET dependence was observed between reproductive death and apoptotic death. The cell-survival values obtained after2 Gy exposure (SF2) were 0.64, 0.13, and 0.24, respectively. A similar trend was found for the RBE values calculated from the initial slope for both apoptosis and reproductive death. These results strongly suggest that the target for both types of cell death is the same.

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Documento generato il 11/07/20 alle ore 07:48:21