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Titolo:
Role of macrophage scavenger receptor in endotoxin shock
Autore:
Kobayashi, Y; Miyaji, C; Watanabe, H; Umezu, H; Hasegawa, G; Abo, T; Arakawa, M; Kamata, N; Suzuki, H; Kodama, T; Naito, M;
Indirizzi:
Niigata Univ, Sch Med, Dept Pathol 2, Niigata 9518510, Japan Niigata UnivNiigata Japan 9518510 Dept Pathol 2, Niigata 9518510, Japan Niigata Univ, Sch Med, Dept Med 2, Niigata 9518510, Japan Niigata Univ Niigata Japan 9518510 d, Dept Med 2, Niigata 9518510, Japan Niigata Univ, Sch Med, Dept Immunol, Niigata 9518510, Japan Niigata Univ Niigata Japan 9518510 Dept Immunol, Niigata 9518510, Japan Chugai Pharmaceut Co Ltd, Shizuoka 412, Japan Chugai Pharmaceut Co Ltd Shizuoka Japan 412 Co Ltd, Shizuoka 412, Japan Univ Tokyo, Adv Sci & Technol Res Ctr, Dept Mol Biol & Med, Tokyo 1538904,Japan Univ Tokyo Tokyo Japan 1538904 Dept Mol Biol & Med, Tokyo 1538904,Japan
Titolo Testata:
JOURNAL OF PATHOLOGY
fascicolo: 2, volume: 192, anno: 2000,
pagine: 263 - 272
SICI:
0022-3417(200010)192:2<263:ROMSRI>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; INTERCELLULAR-ADHESION MOLECULE-1; KUPFFER CELLS; INFLAMMATORY PROTEIN-2; EXPRESSION CLONING; LIGAND-BINDING; LINEAGE CELLS; HOST-DEFENSE; SR-BI; LIPOPOLYSACCHARIDE;
Keywords:
scavenger receptor; knockout mice; endotoxin shock; Kupffer cells; cytokines; neutrophils;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Naito, M Niigata Univ, Sch Med, Dept Pathol 2, Asahimachi Dori 1, Niigata 9518510, Japan Niigata Univ Asahimachi Dori 1 Niigata Japan 9518510 8510, Japan
Citazione:
Y. Kobayashi et al., "Role of macrophage scavenger receptor in endotoxin shock", J PATHOLOGY, 192(2), 2000, pp. 263-272

Abstract

Lipopolysaccharide (LPS) is known to bind to several receptors on macrophages, including CD14 and macrophage scavenger receptor class A types I and II (MSR-A), and stimulates macrophages to release various inflammatory mediators. MSR-A recognizes a broad range of polyanionic ligands such as chemically modified lipoproteins, LPS of Gram-negative bacteria, and lipoteichoic acid of Gram-positive bacteria, suggesting a role in host defence, In this study, mice lacking MSR-A were used to elucidate the role of MSR-A in endotoxin shock. Peritoneal macrophages from MSR-A-deficient (MSR-A(-/-)) mice bound less remarkably to LPS than those from wild-type (MSR-A(+/+)) mice andthe binding activity of MSR-A(+/+) macrophages to LPS was reduced by the addition of an anti-MSR-A antibody. Clearance of LPS in serum was retarded in MSR-A(-/-) mice after intraperitoneal administration of LPS, LPS-induced expression of cytokines in the liver was similar in MSR-A(+/+) and MSR-A(-/-) mice, but levels of interleukin (IL)-1 beta expression and serum IL-1 beta were lower in MSR-A(-/-) mice, Administration of large doses of LPS resulted in a higher mortality of MSR-A(+/+) mice and pretreatment with an IL-1receptor antagonist reduced the mortality. Thus, MSR-A-mediated macrophageactivation plays a negative role in protecting mice from endotoxin shock by enhancing IL-1 beta production by macrophages, Copyright (C) 2000 John Wiley & Sons, Ltd.

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Documento generato il 04/04/20 alle ore 11:20:24