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Titolo:
'Invading edge vs. inner' (edvin) patterns of vascularization: an interplay between angiogenic and vascular survival factors defines the clinical behaviour of non-small cell lung cancer
Autore:
Giatromanolaki, A; Koukourakis, MI; Sivridis, E; OByrne, K; Gatter, KC; Harris, AL;
Indirizzi:
Democritus Univ Thrace, Dept Pathol, Alexandroupolis 68100, Greece Democritus Univ Thrace Alexandroupolis Greece 68100 upolis 68100, Greece Univ Thessalia, Sch Med, Dept Radiotherapy & Oncol, Larisa 41222, Greece Univ Thessalia Larisa Greece 41222 therapy & Oncol, Larisa 41222, Greece Leicester Royal Infirm, Dept Oncol, Leicester LE1 5WW, Leics, England Leicester Royal Infirm Leicester Leics England LE1 5WW WW, Leics, England Oxford Radcliffe Hosp, Dept Cellular Sci, Oxford OX3 7LJ, England Oxford Radcliffe Hosp Oxford England OX3 7LJ ci, Oxford OX3 7LJ, England Oxford Radcliffe Hosp, Imperial Canc Res Fund, Med Oncol Unit, Oxford OX3 7LJ, England Oxford Radcliffe Hosp Oxford England OX3 7LJ it, Oxford OX3 7LJ, England
Titolo Testata:
JOURNAL OF PATHOLOGY
fascicolo: 2, volume: 192, anno: 2000,
pagine: 140 - 149
SICI:
0022-3417(200010)192:2<140:'EVI(P>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; THYMIDINE PHOSPHORYLASE EXPRESSION; TUMOR ANGIOGENESIS; BREAST-CANCER; INDUCED APOPTOSIS; NEO-ANGIOGENESIS; PROGNOSTIC VALUE; CARCINOMA; PROLIFERATION; P53;
Keywords:
non-small cell lung cancer; angiogenesis patterns; vascular survival; VEGF; thymidine phosphorylase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Koukourakis, MI Tumour & Angiogenesis Res Grp, 18 Dimokratias Ave, Iraklion 71306, Crete, Greece Tumour & Angiogenesis Res Grp 18 Dimokratias Ave Iraklion Crete Greece 71306
Citazione:
A. Giatromanolaki et al., "'Invading edge vs. inner' (edvin) patterns of vascularization: an interplay between angiogenic and vascular survival factors defines the clinical behaviour of non-small cell lung cancer", J PATHOLOGY, 192(2), 2000, pp. 140-149

Abstract

Neo-angiogenesis during neoplastic growth involves endothelial mitogenic and migration stimuli produced by cancer or tumour stromal cells. Although this active angiogenesis takes place in the tumour periphery, the process ofvessel growth and survival in inner areas and its clinical role remain largely unexplored, The present study compared the microvessel score (MS) as well as the single endothelial cell score (ECS) in the invading edge and in inner areas of non-small cell lung carcinomas (NSCLCs), Three different patterns of vascular growth mere distinguished: the edvin (edge vs. inner) type 1, where a low NIS was observed in both peripheral and inner tumour areas; the edvin type 2, where a high MS mas noted in the invading front but a low MS in inner areas; and the edvin type 3, where both peripheral and innertumour areas had a high MS. The ECS was high in the invading edge in edvintype 2 and 3 cases and was sharply decreased in both types in inner areas,suggesting that endothelial cell migration is unlikely to contribute to the angiogenic process in areas away from the tumour front. Expression of thevascular endothelial growth factor (VEGF) and of thymidine phosphorylase (TP) was associated with a high MS in the invading edge. VEGF was associated,vith a high MS in inner areas (edvin 3), while TP expression was associated with edvin type 2, showing that VEGF (and not TP) contributes to the preservation of the inner vasculature, Both edvin type 2 and 3 cases showed an increased incidence of node metastasis, but edvin type 3 cases had a poorerprognosis, even in the N1-stage group. The present study suggests that tumour factors regulating angiogenesis and vascular survival are not identical. A possible method is reported to quantify these two parameters by comparing the MS in the invading edge and inner areas (edvin types). This observation may contribute to the evaluation of the effectiveness of different therapeutic approaches, namely vascular targeting vs, antiangiogenesis, Copyright (C) 2000 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 23:02:15