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Titolo:
NPS 1506: A novel NMDA receptor antagonist - Neuroprotective effects in a model of closed head trauma in rats
Autore:
Lorber, A; Artru, AA; Lam, AM; Mueller, AL; Karpas, Z; Roytblat, L; Shapira, S;
Indirizzi:
Univ Washington, Dept Anesthesiol, Sch Med, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 siol, Sch Med, Seattle, WA 98195 USA Nucl Res Ctr Negev, Dept Analyt Chem, IL-84190 Beer Sheva, Israel Nucl ResCtr Negev Beer Sheva Israel IL-84190 L-84190 Beer Sheva, Israel NPS Pharmaceut Inc, Salt Lake City, UT USA NPS Pharmaceut Inc Salt Lake City UT USA eut Inc, Salt Lake City, UT USA Ben Gurion Univ Negev, Fac Hlth Sci, IL-84105 Beer Sheva, Israel Ben Gurion Univ Negev Beer Sheva Israel IL-84105 4105 Beer Sheva, Israel
Titolo Testata:
JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY
fascicolo: 4, volume: 12, anno: 2000,
pagine: 345 - 355
SICI:
0898-4921(200010)12:4<345:N1ANNR>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL BRAIN INJURY; REGIONAL CEREBRAL EDEMA; CONDITIONED FREEZING DEFICIT; RIGHT PARIETAL CORTEX; GLUTAMATE-RECEPTOR; 5-PERCENT DEXTROSE; RAPID INFUSION; INFARCT VOLUME; AMINO-ACIDS; MAGNESIUM;
Keywords:
brain, tissue, ions; edema, brain; head injury, closed; ischemia, brain, tissue volume; neuroprotection; NMDA receptor antagonist;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Artru, AA Univ Washington, Dept Anesthesiol, Sch Med, Box 356540, Seattle,WA 98195 USA Univ Washington Box 356540 Seattle WA USA 98195 le, WA 98195 USA
Citazione:
A. Lorber et al., "NPS 1506: A novel NMDA receptor antagonist - Neuroprotective effects in a model of closed head trauma in rats", J NEUROS AN, 12(4), 2000, pp. 345-355

Abstract

We examined whether NPS 1506, a novel uncompetitive N-methyl-D-aspartate receptor antagonist, influences neurological outcome following closed head trauma (CHT) in rats. One hundred ten rats were divided into 11 groups: CHT (yes/no), treatment with NPS 1506 (yes/no), and time of euthanization (24 h/48 h). The dose of NPS 1506 was 1 mg/kg IV at 1 and 4 hours following CHT or sham operation. Closed head trauma induced the following changes in the injured hemisphere: Decreased specific gravity (sg) (1.036 +/- 0.006) and magnesium (Mg) (0.042 +/- 0.005 mu g/mg) at 24 hours, and potassium (K) at 24 (1.145 +/- 9.376 mu g/mg) and 48 hours, and increased water content (W) (84.9 +/- 2.5%) and sodium (Na) (2.135 +/- 0.699 mu g/mg) at 24 hours, and calcium (Ca) at 24 (0.543 +/- 0.157 mu g/mg) and 48 hours. These were reversed by NPS 1506; sg of 1.043 +/- 0.004, Mg of 0.077 +/- 0.009 mu g/mg, K of 1.930 +/- 0.238 mu g/mg, W of 81.5 +/- 1.9%, Ca of 0.043 +/- 0.023 mu g/mg,and Na of 0.688 +/- 0.110 mu g/mg. In groups not given NPS 1506, a nonsignificant decrease in neurological severity score (NSS) occurred at 24 and 48hours as compared to NSS at 1 hour after CHT. In groups given NPS 1506, NSS at 24 and 48 hours decreased significantly (improved) compared to NSS at 1 hour, but not compared to NSS at 24 and 48 hours in groups not given NPS 1506. NPS 1506 caused no significant change in ischemic tissue volume or hemorrhagic necrosis volume in the injured hemisphere at 24 hours or 48 hours. These findings indicate that NPS 1506 improved measures of brain tissue edema (at 24 hours but not at 48 hours) and ion homeostasis, and this improvement was not related to other measures of outcome.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 14:39:37