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Titolo:
Intracerebral complement C5a receptor (CD88) expression is regulated by TNF and lymphotoxin-alpha following closed head injury in mice
Autore:
Stahel, PF; Kariya, K; Shohami, E; Barnum, SR; Eugster, HP; Trentz, O; Kossmann, T; Morganti-Kossmann, MC;
Indirizzi:
Univ Zurich Hosp, Dept Surg, Div Trauma Surg, CH-8091 Zurich, Switzerland Univ Zurich Hosp Zurich Switzerland CH-8091 CH-8091 Zurich, Switzerland Univ Zurich Hosp, Dept Surg, Div Res, CH-8091 Zurich, Switzerland Univ Zurich Hosp Zurich Switzerland CH-8091 CH-8091 Zurich, Switzerland Hebrew Univ Jerusalem, Hadassah Med Sch, Dept Pharmacol, Jerusalem, IsraelHebrew Univ Jerusalem Jerusalem Israel ept Pharmacol, Jerusalem, Israel Univ Alabama, Dept Microbiol, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 Microbiol, Birmingham, AL 35294 USA Univ Zurich, Dept Med, Clin Immunol Sect, Zurich, Switzerland Univ ZurichZurich Switzerland , Clin Immunol Sect, Zurich, Switzerland
Titolo Testata:
JOURNAL OF NEUROIMMUNOLOGY
fascicolo: 2, volume: 109, anno: 2000,
pagine: 164 - 172
SICI:
0165-5728(20000922)109:2<164:ICCR(E>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; TUMOR-NECROSIS-FACTOR; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; TGW NEUROBLASTOMA-CELLS; TRAUMATIC BRAIN INJURY; SIGNAL-TRANSDUCTION; HUMAN ASTROCYTES; ANAPHYLATOXIN; MICROGLIA; DISEASE;
Keywords:
traumatic brain injury; complement; C5a; serpentine receptors; knockout mice;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Stahel, PF Univ Zurich Hosp, Dept Surg, Div Trauma Surg, CH-8091 Zurich, Switzerland Univ Zurich Hosp Zurich Switzerland CH-8091 rich, Switzerland
Citazione:
P.F. Stahel et al., "Intracerebral complement C5a receptor (CD88) expression is regulated by TNF and lymphotoxin-alpha following closed head injury in mice", J NEUROIMM, 109(2), 2000, pp. 164-172

Abstract

The anaphylatoxin C5a is a potent mediator of inflammation in the CNS. We analyzed the intracerebral expression of the C5a receptor (C5aR) in a modelof closed head injury (CHI) in mice. Up-regulation of C5aR mRNA and protein expression was observed mainly on neurons in sham-operated and head-injured wild-type mice at 24 h. In contrast, in TNF/lymphotoxin-alpha knockout mice, the intracerebral C5aR expression remained at low constitutive levels after sham operation, whereas it strongly increased in response to trauma between 24 and 72 h. Interestingly, by 7 days after CHI, the intrathecal C5aR expression was clearly attenuated in the knockout animals. These data show that the posttraumatic neuronal expression of the C5aR is, at least in part, regulated by TNF and lymphotoxin-alpha at 7 days after trauma. (C) 2000Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/21 alle ore 00:43:59